A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale
| dc.contributor.author | FRANCIS, Z. | |
| hal.structure.identifier | Laboratoire de Physique de Clermont [LPC] | |
| dc.contributor.author | MONTAROU, G. | |
| hal.structure.identifier | Centre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG] | |
| dc.contributor.author | INCERTI, S. | |
| dc.contributor.author | BERNAL, M. | |
| dc.contributor.author | ZEIN, S.A. | |
| dc.date.issued | 2019 | |
| dc.description.abstractEn | This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 × 10 × 10 μm3) water phantom containing a tube of 300 nm diameter and 5 μm length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios. | |
| dc.language.iso | en | |
| dc.title.en | A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.ejmp.2019.10.038 | |
| dc.subject.hal | Physique [physics] | |
| bordeaux.journal | Phys.Medica | |
| bordeaux.page | 148-154 | |
| bordeaux.volume | 67 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-02361417 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-02361417v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Phys.Medica&rft.date=2019&rft.volume=67&rft.spage=148-154&rft.epage=148-154&rft.au=FRANCIS,%20Z.&MONTAROU,%20G.&INCERTI,%20S.&BERNAL,%20M.&ZEIN,%20S.A.&rft.genre=article |
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