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Evaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA

dc.contributor.authorSAKATA, Dousatsu
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorLAMPE, Nathanael
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorKARAMITROS, Mathieu
dc.contributor.authorKYRIAKOU, Ioanna
dc.contributor.authorBELOV, Oleg
dc.contributor.authorBERNAL, Mario A.
dc.contributor.authorBOLST, David
hal.structure.identifierCentre de Recherches en Cancérologie de Toulouse [CRCT]
dc.contributor.authorBORDAGE, Marie-Claude
hal.structure.identifierLaboratoire de Physique de Clermont [LPC]
dc.contributor.authorBRETON, Vincent
dc.contributor.authorBROWN, Jeremy M.C.
dc.contributor.authorFRANCIS, Ziad
dc.contributor.authorIVANCHENKO, Vladimir
hal.structure.identifierLaboratoire de dosimétrie des rayonnements ionisants [IRSN/PSE-SANTE/SDOS/LDRI]
dc.contributor.authorMEYLAN, Sylvain
dc.contributor.authorMURAKAMI, Koichi
dc.contributor.authorOKADA, Shogo
dc.contributor.authorPETROVIC, Ivan
dc.contributor.authorRISTIC-FIRA, Aleksandra
dc.contributor.authorSANTIN, Giovanni
hal.structure.identifierLaboratoire de Physique de Clermont [LPC]
dc.contributor.authorSARRAMIA, David
dc.contributor.authorSASAKI, Takashi
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSHIN, Wook-Geun
hal.structure.identifierInstitut de Radioprotection et de Sûreté Nucléaire [IRSN]
dc.contributor.authorTANG, Nicolas
dc.contributor.authorTRAN, Hoang N.
hal.structure.identifierLaboratoire de dosimétrie des rayonnements ionisants [IRSN/PSE-SANTE/SDOS/LDRI]
dc.contributor.authorVILLAGRASA, Carmen
dc.contributor.authorEMFIETZOGLOU, Dimitris
dc.contributor.authorNIEMINEN, Petteri
dc.contributor.authorGUATELLI, Susanna
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sebastien
dc.date.issued2019
dc.description.abstractEnThe advancement of multidisciplinary research fields dealing with ionising radiation induced biological damage - radiobiology, radiation physics, radiation protection and, in particular, medical physics - requires a clear mechanistic understanding of how cellular damage is induced by ionising radiation. Monte Carlo (MC) simulations provide a promising approach for the mechanistic simulation of radiation transport and radiation chemistry, towards the in silico simulation of early biological damage. We have recently developed a fully integrated MC simulation that calculates early single strand breaks (SSBs) and double strand breaks (DSBs) in a fractal chromatin based human cell nucleus model. The results of this simulation are almost equivalent to past MC simulations when considering direct/indirect strand break fraction, DSB yields and fragment distribution. The simulation results agree with experimental data on DSB yields within 13.6% on average and fragment distributions agree within an average of 34.8%.
dc.language.isoen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/
dc.title.enEvaluation of early radiation DNA damage in a fractal cell nucleus model using Geant4-DNA
dc.typeArticle de revue
dc.identifier.doi10.1016/j.ejmp.2019.04.010
dc.subject.halPhysique [physics]
bordeaux.journalPhys.Medica
bordeaux.page152-157
bordeaux.volume62
bordeaux.peerReviewedoui
hal.identifierhal-02166564
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02166564v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Phys.Medica&rft.date=2019&rft.volume=62&rft.spage=152-157&rft.epage=152-157&rft.au=SAKATA,%20Dousatsu&LAMPE,%20Nathanael&KARAMITROS,%20Mathieu&KYRIAKOU,%20Ioanna&BELOV,%20Oleg&rft.genre=article


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