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Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics

dc.rights.licenseopenen_US
dc.contributor.authorBOMBARDI, C.
dc.contributor.authorGRANDIS, A.
dc.contributor.authorPIVAC, N.
dc.contributor.authorSAGUD, M.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLUCAS, Guillaume
dc.contributor.authorCHAGRAOUI, A.
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
dc.contributor.authorLEMAIRE-MAYO, Valerie
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
hal.structure.identifierCentre National de la Recherche Scientifique [CNRS]
dc.contributor.authorDE DEURWAERDERE, Philippe
dc.contributor.authorDI GIOVANNI, G.
dc.date.accessioned2022-04-15T14:35:02Z
dc.date.available2022-04-15T14:35:02Z
dc.date.issued2021
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136649
dc.description.abstractEnThe hippocampal region receives a dense serotoninergic innervation originating from both medial and dorsal raphe nuclei. This innervation regulates hippocampal activity through the activation of distinct receptor families that are expressed in excitatory and inhibitory neurons, terminals of several afferent neurotransmitter systems, and glial cells. Preclinical and clinical studies indicate that hippocampal dysfunctions are involved in learning and memory deficits, dementia, Alzheimer's disease, epilepsy and mood disorders such as anxiety, depression and post-traumatic syndrome disorder, whereas the hippocampus participates also in the therapeutic mechanisms of numerous medicines. Not surprisingly, several drugs acting via 5-HT mechanisms are efficacious to some extent in some diseases and the link between 5-HT and the hippocampus although clear remains difficult to untangle. For this reason, we review reported data concerning the distribution and the functional roles of the 5-HT receptors in the hippocampal region in health and disease. The impact of the 5-HT systems on the hippocampal function is such that the research of new 5-HT mechanisms and drugs is still very active. It concerns notably drugs acting at the 5-HT1A,2A,2C,4,6 receptor subtypes, in addition to the already existing drugs including the selective serotonin reuptake inhibitors.
dc.language.isoENen_US
dc.publisherElsevieren_US
dc.publisher.locationAmsterdamen_US
dc.source.title5-HT Interaction with Other Neurotransmitters: experimental Evidence and Therapeutic Relevanceen_US
dc.subject.enExcitatory neurons
dc.subject.enHippocampal region
dc.subject.enInterneurons
dc.subject.enNeurochemistry
dc.subject.enNeurodegenerative and psychiatric diseases
dc.subject.enSerotonin
dc.subject.enSerotonin receptor
dc.title.enSerotonin modulation of hippocampal functions: From anatomy to neurotherapeutics
dc.typeChapitre d'ouvrageen_US
dc.identifier.doi10.1016/bs.pbr.2021.01.031en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.page83-158en_US
bordeaux.volume261en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.inpressnonen_US
hal.identifierhal-03643383
hal.version1
hal.date.transferred2022-04-15T14:35:05Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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