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Extracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.

dc.rights.licenseopenen_US
dc.contributor.authorNESSELER, Nicolas
dc.contributor.authorFADEL, Guillaume
dc.contributor.authorMANSOUR, Alexandre
dc.contributor.authorPARA, Marylou
dc.contributor.authorFALCOZ, Pierre-Emmanuel
dc.contributor.authorMONGARDON, Nicolas
dc.contributor.authorPORTO, Alizée
dc.contributor.authorBERTIER, Astrid
dc.contributor.authorLEVY, Bruno
dc.contributor.authorCADOZ, Cyril
dc.contributor.authorGUINOT, Pierre-Grégoire
dc.contributor.authorFOUQUET, Olivier
dc.contributor.authorFELLAHI, Jean-Luc
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorOUATTARA, Alexandre
dc.contributor.authorGUIHAIRE, Julien
dc.contributor.authorRUGGIERI, Vito-Giovanni
dc.contributor.authorGAUDARD, Philippe
dc.contributor.authorLABASTE, François
dc.contributor.authorCLAVIER, Thomas
dc.contributor.authorBRINI, Kais
dc.contributor.authorALLOU, Nicolas
dc.contributor.authorLACROIX, Corentin
dc.contributor.authorCHOMMELOUX, Juliette
dc.contributor.authorLEBRETON, Guillaume
dc.contributor.authorMATTHAY, Michael A
dc.contributor.authorPROVENCHERE, Sophie
dc.contributor.authorFLÉCHER, Erwan
dc.contributor.authorVINCENTELLI, André
dc.date.accessioned2022-04-07T12:23:30Z
dc.date.available2022-04-07T12:23:30Z
dc.date.issued2022-03-29
dc.identifier.issn1528-1175en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136610
dc.description.abstractEnDespite expanding use, knowledge on extracorporeal membrane oxygenation support during the COVID-19 pandemic remains limited. The objective was to report characteristics, management, and outcomes of patients receiving extracorporeal membrane oxygenation with a diagnosis of COVID-19 in France and to identify pre-extracorporeal membrane oxygenation factors associated with in-hospital mortality. A hypothesis of similar mortality rates and risk factors for COVID-19 and non-COVID-19 patients on venovenous extracorporeal membrane oxygenation was made. The Extracorporeal Membrane Oxygenation for Respiratory Failure and/or Heart failure related to Severe Acute Respiratory Syndrome-Coronavirus 2 (ECMOSARS) registry included COVID-19 patients supported by extracorporeal membrane oxygenation in France. This study analyzed patients included in this registry up to October 25, 2020, and supported by venovenous extracorporeal membrane oxygenation for respiratory failure with a minimum follow-up of 28 days after cannulation. The primary outcome was in-hospital mortality. Risk factors for in-hospital mortality were analyzed. Among 494 extracorporeal membrane oxygenation patients included in the registry, 429 were initially supported by venovenous extracorporeal membrane oxygenation and followed for at least 28 days. The median (interquartile range) age was 54 yr (46 to 60 yr), and 338 of 429 (79%) were men. Management before extracorporeal membrane oxygenation cannulation included prone positioning for 411 of 429 (96%), neuromuscular blockage for 419 of 427 (98%), and NO for 161 of 401 (40%). A total of 192 of 429 (45%) patients were cannulated by a mobile extracorporeal membrane oxygenation unit. In-hospital mortality was 219 of 429 (51%), with a median follow-up of 49 days (33 to 70 days). Among pre-extracorporeal membrane oxygenation modifiable exposure variables, neuromuscular blockage use (hazard ratio, 0.286; 95% CI, 0.101 to 0.81) and duration of ventilation (more than 7 days compared to less than 2 days; hazard ratio, 1.74; 95% CI, 1.07 to 2.83) were independently associated with in-hospital mortality. Both age (per 10-yr increase; hazard ratio, 1.27; 95% CI, 1.07 to 1.50) and total bilirubin at cannulation (6.0 mg/dl or more compared to less than 1.2 mg/dl; hazard ratio, 2.65; 95% CI, 1.09 to 6.5) were confounders significantly associated with in-hospital mortality. In-hospital mortality was higher than recently reported, but nearly half of the patients survived. A high proportion of patients were cannulated by a mobile extracorporeal membrane oxygenation unit. Several factors associated with mortality were identified. Venovenous extracorporeal membrane oxygenation support should be considered early within the first week of mechanical ventilation initiation.
dc.language.isoENen_US
dc.subject.encovid-19
dc.subject.enextracorporeal membrane oxygenation
dc.subject.enhospitals
dc.subject.enuniversity
dc.subject.enrespiratory insufficiency
dc.title.enExtracorporeal Membrane Oxygenation for Respiratory Failure Related to COVID-19: A Nationwide Cohort Study.
dc.title.alternativeAnesthesiologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/ALN.0000000000004168en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed35348610en_US
bordeaux.journalAnesthesiologyen_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires (BMC) - UMR 1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Anesthesiology&rft.date=2022-03-29&rft.eissn=1528-1175&rft.issn=1528-1175&rft.au=NESSELER,%20Nicolas&FADEL,%20Guillaume&MANSOUR,%20Alexandre&PARA,%20Marylou&FALCOZ,%20Pierre-Emmanuel&rft.genre=article


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