DESMEDT, Aline

doi:10.1177/24705470211021073

Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]

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Article de revue

Ce document a été publié dans

Chronic Stress. 2021-05-26, vol. 5

Résumé en anglais

A cardinal feature of Post-traumatic stress-related disorder (PTSD) is a paradoxical memory alteration including both intrusive emotional hypermnesia and declarative/contextual amnesia. Most preclinical, but also numerous clinical, studies focus almost exclusively on the emotional hypermnesia aiming at suppressing this recurrent and highly debilitating symptom either by reducing fear and anxiety or with the ethically questionable idea of a rather radical erasure of traumatic memory. Of very mixed efficacy, often associated with a resurgence of symptoms after a while, these approaches focus on PTSD-related symptom while neglecting the potential cause of this symptom: traumatic amnesia. Two of our preclinical studies have recently demonstrated that treating contextual amnesia durably prevents, and even treats, PTSD-related hypermnesia. Specifically, promoting the contextual memory of the trauma, either by a cognitivo-behavioral, optogenetic or pharmacological approach enhancing a hippocampus-dependent memory processing of the trauma normalizes the fear memory by inducing a long-lasting suppression of the erratic traumatic hypermnesia.< Réduire

Mots clés en anglais

Contextual amnesia

Emotional hypermnesia

Hippocampus

PTSD

Traumatic memory

URI

https://oskar-bordeaux.fr/handle/20.500.12278/136593

DOI

http://dx.doi.org/10.1177/24705470211021073

Project ANR

Altérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatique - ANR-14-CE13-0026

Unités de recherche

Neurocentre Magendie - U1215

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(Re)contextualizing the Trauma to Prevent or Treat PTSD-Related Hypermnesia