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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDESMEDT, Aline
dc.date.accessioned2022-04-04T12:21:53Z
dc.date.available2022-04-04T12:21:53Z
dc.date.issued2021-05-26
dc.identifier.issn2470-5470en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136593
dc.description.abstractEnA cardinal feature of Post-traumatic stress-related disorder (PTSD) is a paradoxical memory alteration including both intrusive emotional hypermnesia and declarative/contextual amnesia. Most preclinical, but also numerous clinical, studies focus almost exclusively on the emotional hypermnesia aiming at suppressing this recurrent and highly debilitating symptom either by reducing fear and anxiety or with the ethically questionable idea of a rather radical erasure of traumatic memory. Of very mixed efficacy, often associated with a resurgence of symptoms after a while, these approaches focus on PTSD-related symptom while neglecting the potential cause of this symptom: traumatic amnesia. Two of our preclinical studies have recently demonstrated that treating contextual amnesia durably prevents, and even treats, PTSD-related hypermnesia. Specifically, promoting the contextual memory of the trauma, either by a cognitivo-behavioral, optogenetic or pharmacological approach enhancing a hippocampus-dependent memory processing of the trauma normalizes the fear memory by inducing a long-lasting suppression of the erratic traumatic hypermnesia.
dc.description.sponsorshipAltérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatique - ANR-14-CE13-0026en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enContextual amnesia
dc.subject.enEmotional hypermnesia
dc.subject.enHippocampus
dc.subject.enPTSD
dc.subject.enTraumatic memory
dc.title.en(Re)contextualizing the Trauma to Prevent or Treat PTSD-Related Hypermnesia
dc.title.alternativeChronic Stressen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/24705470211021073en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34104834en_US
bordeaux.journalChronic Stressen_US
bordeaux.volume5en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDMinistère de l'Enseignement Supérieur et de la Recherche Scientifiqueen_US
hal.identifierhal-03967191
hal.version1
hal.date.transferred2023-02-01T10:02:48Z
hal.exporttrue
dc.rights.ccCC BY-NCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Chronic%20Stress&rft.date=2021-05-26&rft.volume=5&rft.eissn=2470-5470&rft.issn=2470-5470&rft.au=DESMEDT,%20Aline&rft.genre=article


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