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Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts

dc.rights.licenseopenen_US
dc.contributor.authorSHARMIN, S.
dc.contributor.authorLEFORT, M.
dc.contributor.authorANDERSEN, J.B.
dc.contributor.authorLERAY, E.
dc.contributor.authorHORAKOVA, D.
dc.contributor.authorHAVRDOVA, E.K.
dc.contributor.authorALROUGHANI, R.
dc.contributor.authorIZQUIERDO, G.
dc.contributor.authorOZAKBAS, S.
dc.contributor.authorPATTI, F.
dc.contributor.authorONOFRJ, M.
dc.contributor.authorLUGARESI, A.
dc.contributor.authorTERZI, M.
dc.contributor.authorGRAMMOND, P.
dc.contributor.authorGRAND’MAISON, F.
dc.contributor.authorYAMOUT, B.
dc.contributor.authorPRAT, A.
dc.contributor.authorGIRARD, M.
dc.contributor.authorDUQUETTE, P.
dc.contributor.authorBOZ, C.
dc.contributor.authorTROJANO, M.
dc.contributor.authorMCCOMBE, P.
dc.contributor.authorSLEE, M.
dc.contributor.authorLECHNER-SCOTT, J.
dc.contributor.authorTURKOGLU, R.
dc.contributor.authorSOLA, P.
dc.contributor.authorFERRARO, D.
dc.contributor.authorGRANELLA, F.
dc.contributor.authorPREVOST, J.
dc.contributor.authorMAIMONE, D.
dc.contributor.authorSKIBINA, O.
dc.contributor.authorBUZZARD, K.
dc.contributor.authorVAN DER WALT, A.
dc.contributor.authorVAN WIJMEERSCH, B.
dc.contributor.authorCSEPANY, T.
dc.contributor.authorSPITALERI, D.
dc.contributor.authorVUCIC, S.
dc.contributor.authorCASEY, R.
dc.contributor.authorDEBOUVERIE, M.
dc.contributor.authorEDAN, G.
dc.contributor.authorCIRON, J.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorDE SEZE, J.
dc.contributor.authorMAILLART, E.
dc.contributor.authorZEPHIR, H.
dc.contributor.authorLABAUGE, P.
dc.contributor.authorDEFER, G.
dc.contributor.authorLEBRUN-FRENAY, C.
dc.contributor.authorMOREAU, T.
dc.contributor.authorBERGER, E.
dc.contributor.authorCLAVELOU, P.
dc.contributor.authorPELLETIER, J.
dc.contributor.authorSTANKOFF, B.
dc.contributor.authorGOUT, O.
dc.contributor.authorTHOUVENOT, E.
dc.contributor.authorHEINZLEF, O.
dc.contributor.authorAL-KHEDR, A.
dc.contributor.authorBOURRE, B.
dc.contributor.authorCASEZ, O.
dc.contributor.authorCABRE, P.
dc.contributor.authorMONTCUQUET, A.
dc.contributor.authorWAHAB, A.
dc.contributor.authorCAMDESSANCHE, J.-P.
dc.contributor.authorMAUROUSSET, A.
dc.contributor.authorPATRY, I.
dc.contributor.authorHANKIEWICZ, K.
dc.contributor.authorPOTTIER, C.
dc.contributor.authorMAUBEUGE, N.
dc.contributor.authorLABEYRIE, C.
dc.contributor.authorNIFLE, C.
dc.contributor.authorLAPLAUD, D.
dc.contributor.authorKOCH-HENRIKSEN, N.
dc.contributor.authorSELLEBJERG, F.T.
dc.contributor.authorSOERENSEN, P.S.
dc.contributor.authorPFLEGER, C.C.
dc.contributor.authorRASMUSSEN, P.V.
dc.contributor.authorJENSEN, M.B.
dc.contributor.authorFREDERIKSEN, J.L.
dc.contributor.authorBRAMOW, S.
dc.contributor.authorMATHIESEN, H.K.
dc.contributor.authorSCHREIBER, K.I.
dc.contributor.authorMAGYARI, M.
dc.contributor.authorVUKUSIC, S.
dc.contributor.authorBUTZKUEVEN, H.
dc.contributor.authorKALINCIK, T.
dc.date.accessioned2022-03-29T13:47:08Z
dc.date.available2022-03-29T13:47:08Z
dc.date.issued2021-11
dc.identifier.issn1179-1934 (online) 1172-7047 (print)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136548
dc.description.abstractEnIntroduction : Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined. Objective : The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Methods : Patients with RRMS who were given natalizumab or fingolimod were identified in a merged cohort from three international registries. Efficacy outcomes were compared across subgroups based on patients’ sex, age, disease duration, Expanded Disability Status Scale (EDSS) score, and disease and magnetic resonance imaging (MRI) activity 12 months prior to treatment initiation. Study endpoints were number of relapses (analyzed with weighted negative binomial generalized linear model) and 6-month confirmed disability worsening and improvement events (weighted Cox proportional hazards model), recorded during study therapy. Each patient was weighted using inverse probability of treatment weighting based on propensity score. Results : A total of 5148 patients (natalizumab 1989; fingolimod 3159) were included, with a mean ± standard deviation age at baseline of 38 ± 10 years, and the majority (72%) were women. The median on-treatment follow-up was 25 (quartiles 15–41) months. Natalizumab was associated with fewer relapses than fingolimod (incidence rate ratio [IRR]; 95% confidence interval [CI]) in women (0.76; 0.65–0.88); in those aged ≤ 38 years (0.64; 0.54–0.76); in those with disease duration ≤ 7 years (0.63; 0.53–0.76); in those with EDSS score < 4 (0.75; 0.64–0.88), < 6 (0.80; 0.70–0.91), and ≥ 6 (0.52; 0.31–0.86); and in patients with pre-baseline relapses (0.74; 0.64–0.86). A higher probability of confirmed disability improvement on natalizumab versus fingolimod (hazard ratio [HR]; 95% CI) was observed among women (1.36; 1.10–1.66); those aged > 38 years (1.34; 1.04–1.73); those with disease duration > 7 years (1.33; 1.01–1.74); those with EDSS score < 6 (1.21; 1.01–1.46) and ≥ 6 (1.93; 1.11–3.34); and patients with no new MRI lesion (1.73; 1.19–2.51). Conclusions : Overall, in women, younger patients, those with shorter disease durations, and patients with pre-treatment relapses, natalizumab was associated with a lower frequency of multiple sclerosis relapses than fingolimod. It was also associated with an increased chance of recovery from disability among most patients, particularly women and those with no recent MRI activity.
dc.language.isoENen_US
dc.title.enNatalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s40263-021-00860-7en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34536228en_US
bordeaux.journalCNS drugsen_US
bordeaux.page1217-1232en_US
bordeaux.volume35en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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