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Reactive astrocyte nomenclature, definitions, and future directions

dc.rights.licenseopenen_US
dc.contributor.authorESCARTIN, Carole
dc.contributor.authorGALEA, Elena
dc.contributor.authorLAKATOS, Andras
dc.contributor.authorO’CALLAGHAN, James P.
dc.contributor.authorPETZOLD, Gabor C.
dc.contributor.authorSERRANO-POZO, Alberto
dc.contributor.authorSTEINHAUSER, Christian
dc.contributor.authorVOLTERRA, Andrea
dc.contributor.authorCARMIGNOTO, Giorgio
dc.contributor.authorAGARWAL, Amit
dc.contributor.authorALLEN, Nicola J.
dc.contributor.authorARAQUE, Alfonso
dc.contributor.authorBARBEITO, Luis
dc.contributor.authorBARZILAI, Ari
dc.contributor.authorBERGLES, Dwight E.
dc.contributor.authorBONVENTO, Gilles
dc.contributor.authorBUTT, Arthur M.
dc.contributor.authorCHEN, Wei-Ting
dc.contributor.authorCOHEN-SALMON, Martine
dc.contributor.authorCUNNINGHAM, Colm
dc.contributor.authorDENEEN, Benjamin
dc.contributor.authorDE STROOPER, Bart
dc.contributor.authorDIAZ-CASTRO, Blanca
dc.contributor.authorFARINA, Cinthia
dc.contributor.authorFREEMAN, Marc
dc.contributor.authorGALLO, Vittorio
dc.contributor.authorGOLDMAN, James E.
dc.contributor.authorGOLDMAN, Steven A.
dc.contributor.authorGOTZ, Magdalena
dc.contributor.authorGUTIERREZ, Antonia
dc.contributor.authorHAYDON, Philip G.
dc.contributor.authorHEILAND, Dieter H.
dc.contributor.authorHOL, Elly M.
dc.contributor.authorHOLT, Matthew G.
dc.contributor.authorLINO, Masamitsu
dc.contributor.authorKASTANENKA, Ksenia V.
dc.contributor.authorKETTENMANN, Helmut
dc.contributor.authorKHAKH, Baljit S.
dc.contributor.authorKOIZUMI, Schuichi
dc.contributor.authorLEE, C. Justin
dc.contributor.authorLIDDELOW, Shane A.
dc.contributor.authorMAC VICAR, Brian A.
dc.contributor.authorMAGISTRETTI, Pierre
dc.contributor.authorMESSING, Albee
dc.contributor.authorMISHRA, Anusha
dc.contributor.authorMOLOFSKY, Anna V.
dc.contributor.authorMURAI, Keith K.
dc.contributor.authorNORRIS, Christopher M.
dc.contributor.authorOKADA, Seiji
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorOLIET, Stéphane
dc.contributor.authorOLIVEIRA, Joao F.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPANATIER, Aude
dc.contributor.authorPARPURA, Vladimir
dc.contributor.authorPEKNA, Marcela
dc.contributor.authorPEKNY, Milos
dc.contributor.authorPELLERIN, Luc
dc.contributor.authorPEREA, Gertrudis
dc.contributor.authorPEREZ-NIEVAS, Beatriz G.
dc.contributor.authorPFRIEGER, Frank W.
dc.contributor.authorPOSKANZER, Kira E.
dc.contributor.authorQUINTANA, Francisco J.
dc.contributor.authorRANSOHOFF, Richard M.
dc.contributor.authorRIQUELME-PEREZ, Miriam
dc.contributor.authorROBEL, Stefanie
dc.contributor.authorROSE, Christine R.
dc.contributor.authorROTHSTEIN, Jeffrey D.
dc.contributor.authorROUACH, Nathalie
dc.contributor.authorROWITCH, David H.
dc.contributor.authorSEMYANOV, Alexey
dc.contributor.authorSIRKO, Swetlana
dc.contributor.authorSONTHEIMER, Harald
dc.contributor.authorSWANSON, Raymond A.
dc.contributor.authorVITORICA, Javier
dc.contributor.authorWANNER, Ina-Beate
dc.contributor.authorWOOD, Levi B.
dc.contributor.authorWU, Jiaqian
dc.contributor.authorZHENG, Binhai
dc.contributor.authorZIMMER, Eduardo R.
dc.contributor.authorZOREC, Robert
dc.contributor.authorSOFRONIEW, Michael V
dc.contributor.authorVERKHRATSKY, Alexei
dc.date.accessioned2022-03-23T10:05:23Z
dc.date.available2022-03-23T10:05:23Z
dc.date.issued2021-03
dc.identifier.issn1546-1726en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136517
dc.description.abstractEnReactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters—preferably in vivo—plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions.
dc.language.isoENen_US
dc.title.enReactive astrocyte nomenclature, definitions, and future directions
dc.title.alternativeNat Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41593-020-00783-4en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33589835en_US
bordeaux.journalNature Neuroscienceen_US
bordeaux.page312-325en_US
bordeaux.volume24en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDCommissariat à l'Énergie Atomique et aux Énergies Alternativesen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDAssociation France Alzheimeren_US
bordeaux.identifier.funderIDHeidi Seiler-Stiftungen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Neuroscience&rft.date=2021-03&rft.volume=24&rft.issue=3&rft.spage=312-325&rft.epage=312-325&rft.eissn=1546-1726&rft.issn=1546-1726&rft.au=ESCARTIN,%20Carole&GALEA,%20Elena&LAKATOS,%20Andras&O%E2%80%99CALLAGHAN,%20James%20P.&PETZOLD,%20Gabor%20C.&rft.genre=article


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