The neuroimmune basis of fatigue.
| dc.rights.license | open | en_US |
| hal.structure.identifier | The University of Texas Medical Branch [UTMB] | |
| dc.contributor.author | DANTZER, Robert | |
| hal.structure.identifier | The University of Texas Medical Branch [UTMB] | |
| dc.contributor.author | HEIJNEN, Cobi Johanna | |
| hal.structure.identifier | The University of Texas Medical Branch [UTMB] | |
| dc.contributor.author | KAVELAARS, Annemieke | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| dc.date.accessioned | 2022-03-16T15:18:18Z | |
| dc.date.available | 2022-03-16T15:18:18Z | |
| dc.date.issued | 2014-01-01 | |
| dc.identifier.issn | 1878-108X | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136492 | |
| dc.description.abstractEn | The exact nature and pathophysiology of fatigue remain largely elusive despite its high prevalence in physically ill patients. Studies on the relationship between the immune system and the central nervous system provide a new perspective on the mechanisms of fatigue. Inflammatory mediators that are released by activated innate immune cells at the periphery and in the central nervous system alter the metabolism and activity of neurotransmitters, generate neurotoxic compounds, decrease neurotrophic factors, and profoundly disturb the neuronal environment. The resulting alterations in fronto-striatal networks together with the activation of insula by inflammatory interoceptive stimuli underlie the many dimensions of fatigue including reduced incentive motivation, decreased behavioral flexibility, uncertainty about usefulness of actions, and awareness of fatigue. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Fatigue | |
| dc.subject.en | Humans | |
| dc.subject.en | Neuroimmunomodulation | |
| dc.title.en | The neuroimmune basis of fatigue. | |
| dc.title.alternative | Trends Neurosci | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.tins.2013.10.003 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 24239063 | en_US |
| bordeaux.journal | Trends in Neurosciences | en_US |
| bordeaux.page | 39-46 | en_US |
| bordeaux.volume | 37 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Trends%20in%20Neurosciences&rft.date=2014-01-01&rft.volume=37&rft.issue=1&rft.spage=39-46&rft.epage=39-46&rft.eissn=1878-108X&rft.issn=1878-108X&rft.au=DANTZER,%20Robert&HEIJNEN,%20Cobi%20Johanna&KAVELAARS,%20Annemieke&LAYE,%20Sophie&CAPURON,%20Lucile&rft.genre=article |
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