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dc.rights.licenseopenen_US
hal.structure.identifierThe University of Texas Medical Branch [UTMB]
dc.contributor.authorDANTZER, Robert
hal.structure.identifierThe University of Texas Medical Branch [UTMB]
dc.contributor.authorHEIJNEN, Cobi Johanna
hal.structure.identifierThe University of Texas Medical Branch [UTMB]
dc.contributor.authorKAVELAARS, Annemieke
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.date.accessioned2022-03-16T15:18:18Z
dc.date.available2022-03-16T15:18:18Z
dc.date.issued2014-01-01
dc.identifier.issn1878-108Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136492
dc.description.abstractEnThe exact nature and pathophysiology of fatigue remain largely elusive despite its high prevalence in physically ill patients. Studies on the relationship between the immune system and the central nervous system provide a new perspective on the mechanisms of fatigue. Inflammatory mediators that are released by activated innate immune cells at the periphery and in the central nervous system alter the metabolism and activity of neurotransmitters, generate neurotoxic compounds, decrease neurotrophic factors, and profoundly disturb the neuronal environment. The resulting alterations in fronto-striatal networks together with the activation of insula by inflammatory interoceptive stimuli underlie the many dimensions of fatigue including reduced incentive motivation, decreased behavioral flexibility, uncertainty about usefulness of actions, and awareness of fatigue.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enFatigue
dc.subject.enHumans
dc.subject.enNeuroimmunomodulation
dc.title.enThe neuroimmune basis of fatigue.
dc.title.alternativeTrends Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.tins.2013.10.003en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed24239063en_US
bordeaux.journalTrends in Neurosciencesen_US
bordeaux.page39-46en_US
bordeaux.volume37en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Trends%20in%20Neurosciences&rft.date=2014-01-01&rft.volume=37&rft.issue=1&rft.spage=39-46&rft.epage=39-46&rft.eissn=1878-108X&rft.issn=1878-108X&rft.au=DANTZER,%20Robert&HEIJNEN,%20Cobi%20Johanna&KAVELAARS,%20Annemieke&LAYE,%20Sophie&CAPURON,%20Lucile&rft.genre=article


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