POMC neuronal heterogeneity in energy balance and beyond: an integrated view
| dc.rights.license | open | en_US |
| atmire.cua.enabled | ||
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | QUARTA, Carmelo | |
| dc.contributor.author | CLARET, Marc | |
| dc.contributor.author | ZELTSER, Lori M. | |
| dc.contributor.author | WILLIAMS, Kevin W. | |
| dc.contributor.author | YEO, Giles S. H. | |
| dc.contributor.author | TSCHOP, Matthias H. | |
| dc.contributor.author | DIANO, Sabrina | |
| dc.contributor.author | BRUNING, Jens C. | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| dc.date.accessioned | 2022-03-16T12:13:05Z | |
| dc.date.available | 2022-03-16T12:13:05Z | |
| dc.date.issued | 2021-03 | |
| dc.identifier.issn | 2522-5812 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136488 | |
| dc.description.abstractEn | Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of the body’s energy status, since they act in an opposite manner to modulate appetite and systemic energy metabolism. However, although AgRP neurons’ functions are comparatively well understood, a unifying theory of how POMC neuronal cells operate has remained elusive, probably due to their high level of heterogeneity, which suggests that their physiological roles might be more complex than initially thought. In this Perspective, we propose a conceptual framework that integrates POMC neuronal heterogeneity with appetite regulation, whole-body metabolic physiology and the development of obesity. We highlight emerging evidence indicating that POMC neurons respond to distinct combinations of interoceptive signals and food-related cues to fine-tune divergent metabolic pathways and behaviours necessary for survival. The new framework we propose reflects the high degree of developmental plasticity of this neuronal population and may enable progress towards understanding of both the aetiology and treatment of metabolic disorders. | |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.description.sponsorship | Innovations instrumentales et procédurales en psychopathologie expérimentale chez le rongeur | en_US |
| dc.description.sponsorship | La signalisation des acides biliaires dans le cerveau et son rôle dans le contrôle métabolique | en_US |
| dc.description.sponsorship | Rôle du récepteur aux cannabinoïdes de type 1 mitochondriale dans les circuits hypothalamiques et son interaction avec la voie mTORC1 dans l'obésité. | en_US |
| dc.description.sponsorship | Rôle de Tbx3 dans la détermination de l'identité fonctionnelle des neurones POMC dans l'obésité - ANR-20-CE14-0046 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | * | |
| dc.rights.uri | * | |
| dc.title.en | POMC neuronal heterogeneity in energy balance and beyond: an integrated view | |
| dc.title.alternative | Nat Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s42255-021-00345-3 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33633406 | en_US |
| dc.description.sponsorshipEurope | European Union Seventh Framework Programme FP7/2007-2013 | en_US |
| bordeaux.journal | Nature Metabolism | en_US |
| bordeaux.page | 299-308 | en_US |
| bordeaux.volume | 3 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Société Française d’Endocrinologie | en_US |
| bordeaux.identifier.funderID | Société Française de Nutrition | en_US |
| bordeaux.identifier.funderID | Société Francophone du Diabète | en_US |
| bordeaux.identifier.funderID | H2020 European Research Council | en_US |
| bordeaux.identifier.funderID | Generalitat de Catalunya | en_US |
| hal.identifier | hal-03610426 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-03-16T12:13:09Z | |
| hal.export | true | |
| dc.rights.cc | en_US | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Metabolism&rft.date=2021-03&rft.volume=3&rft.issue=3&rft.spage=299-308&rft.epage=299-308&rft.eissn=2522-5812&rft.issn=2522-5812&rft.au=QUARTA,%20Carmelo&CLARET,%20Marc&ZELTSER,%20Lori%20M.&WILLIAMS,%20Kevin%20W.&YEO,%20Giles%20S.%20H.&rft.genre=article |
