Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile
IDREF: 167018736 | |
| dc.contributor.author | GEISLER, Simon | |
| dc.contributor.author | KURZ, Katharina | |
| dc.contributor.author | LEBLHUBER, Friedrich | |
| dc.contributor.author | SPERNER-UNTERWEGER, Barbara | |
| dc.contributor.author | FUCHS, Dietmar | |
| dc.date.accessioned | 2022-03-16T10:59:52Z | |
| dc.date.available | 2022-03-16T10:59:52Z | |
| dc.date.issued | 2014-01-01 | |
| dc.identifier.issn | 1873-4286 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136486 | |
| dc.description.abstractEn | Immune activation not only accompanies inflammation in various disorders including infections, autoimmune syndromes and cancer, but it also represents a characteristic feature of ageing. Immune deviations which are most widely expressed in the elderly include increased neopterin production and tryptophan breakdown. These biochemical events result from the activation of the immune system and are preferentially triggered by pro-inflammatory stimuli, such as the Th1-type cytokine interferon-γ. They seem to play a role in the development of several age-related disorders and might be involved in the pathogenesis of common symptoms, including neurobehavioral disorders (e.g., cognitive and mood disturbances), anemia, cachexia, weight-loss but also immunodeficiency. Concentrations of the biomarkers neopterin and Kyn/Trp were found to be predictive of overall disease specific mortality in coronary artery disease, infections and various types of cancer. Immune activation and inflammation are also accompanied by high output of reactive oxygen species and thereby may lead to the development of oxidative stress and contribute to the vitamin deficiency which is often observed in the elderly. Accordingly, increases in neopterin were found to correlate with a substantial decline in key vitamins, including folate and vitamin-B6, - B12, -C, -D and -E. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aging | |
| dc.subject.en | Animals | |
| dc.subject.en | Health Status | |
| dc.subject.en | Humans | |
| dc.subject.en | Immunity | |
| dc.subject.en | Cellular | |
| dc.subject.en | Inflammation | |
| dc.subject.en | Neopterin | |
| dc.subject.en | Oxidative Stress | |
| dc.subject.en | Reactive Oxygen Species | |
| dc.subject.en | Tryptophan | |
| dc.title.en | Activated immune system and inflammation in healthy ageing: relevance for tryptophan and neopterin metabolism. | |
| dc.title.alternative | Curr Pharm Des | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2174/1381612820666140317110217 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 24641220 | en_US |
| bordeaux.journal | Current Pharmaceutical Design | en_US |
| bordeaux.page | 6048-57 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.issue | 38 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Current%20Pharmaceutical%20Design&rft.date=2014-01-01&rft.volume=20&rft.issue=38&rft.spage=6048-57&rft.epage=6048-57&rft.eissn=1873-4286&rft.issn=1873-4286&rft.au=CAPURON,%20Lucile&GEISLER,%20Simon&KURZ,%20Katharina&LEBLHUBER,%20Friedrich&SPERNER-UNTERWEGER,%20Barbara&rft.genre=article |
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