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Adrenal BORDeAux reGistry: Bordeaux single-center study of hypertensive patients with primary hyperaldosteronism

dc.rights.licenseopenen_US
dc.contributor.authorBENOIT, Julie
dc.contributor.authorGAUDISSARD, Julie
dc.contributor.authorDOUBLET, Julien
dc.contributor.authorBOULESTREAUW, Romain
dc.contributor.authorROBERT, Gregoire
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorBROSSAUD, Julie
dc.contributor.authorGOSSE, Philippe
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCREMER, Antoine
dc.date.accessioned2022-03-16T09:15:28Z
dc.date.available2022-03-16T09:15:28Z
dc.date.issued2022-02-18
dc.identifier.issn1473-5598 (Electronic) 0263-6352 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136477
dc.description.abstractEnBACKGROUND: Primary aldosteronism is responsible for a major cardiovascular risk that can be avoided by specific treatment. A better characterization of the hypertensive population with primary aldosteronism would not only improve the overall diagnosis but also allows a better selection of patients requiring adrenal vein sampling (AVS). METHODS: Creation of a prospective single-center Bordeaux ABORDAGE study of hypertensive patients with primary aldosteronism who underwent AVS. Primary aldosteronism was diagnosed according to the recommendations of the SFE/SFHTA. Peripheral and central blood pressure measurements were performed with mercury sphygmomanometer, SphygmoCor applanation tonometer and ambulatory blood pressure measurement. An adrenal computed tomography and an unstimulated AVS were performed in each patient. RESULTS: One hundred and eighty-eight patients were included in our study. They were mostly men (61.7%), with a mean age of 48.7 ± 10.5 years, BMI of 29.7 ± 5 kg/m2 and duration of hypertension of 101.5 ± 84 months. AVS was selective in 82.3% of patients and lateralization was concordant with CT in only 35.4% of patients. Lateralized secretion was significantly associated with a marked biological primary aldosteronism and hypertension. In multivariate analysis, no variable specifically differentiated patients with aldosterone lateralization. CONCLUSION: The ABORDAGE population description is consistent with the data found in the literature. These characteristics are ultimately those expected in essential hypertension population, which therefore, could explain part of the underdiagnosis of primary aldosteronism. Only AVS is able to predict the lateralization of secretion with a post adrenalectomy recovery of about 90% in case of lateralization. The generalization of AVS would, therefore, increase the proportion of patients with primary aldosteronism cured.
dc.language.isoENen_US
dc.title.enAdrenal BORDeAux reGistry: Bordeaux single-center study of hypertensive patients with primary hyperaldosteronism
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/hjh.0000000000003091en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35185118en_US
bordeaux.journalJournal of Hypertensionen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRAE
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03610070
hal.version1
hal.date.transferred2022-03-16T09:15:30Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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