Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g‐computation
| dc.rights.license | open | en_US |
| dc.contributor.author | LETELLIER, Noemie | |
| dc.contributor.author | GUTIERREZ, Laure‐Anne | |
| dc.contributor.author | DUCHESNE, Jeanne | |
| dc.contributor.author | CHEN, Chen | |
| dc.contributor.author | ILANGO, Sindana | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | BERR, Claudine | |
| dc.contributor.author | MORTAMAIS, Marion | |
| dc.contributor.author | BENMARHNIA, Tarik | |
| dc.date.accessioned | 2022-03-11T14:27:42Z | |
| dc.date.available | 2022-03-11T14:27:42Z | |
| dc.date.issued | 2022-02-09 | |
| dc.identifier.issn | 1552-5279 (Electronic) 1552-5260 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136446 | |
| dc.description.abstractEn | INTRODUCTION: No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia-incidence benefits. METHODS: In the French Three-City cohort (12 years of follow-up), we used parametric g-computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 mum (PM2.5 ) reductions. RESULTS: Among 7051 participants, 789 participants developed dementia. The median PM2.5 reduction between 1990 and 2000 was 12.2 (mug/m(3) ). Such a reduction reduced the risk of all-cause dementia (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.76 to 0.95). If all study participants were enjoying a hypothetical reduction of more than 13.10 mug/m(3) (median reduction observed in the city of Montpellier), the rate difference was -0.37 (95% CI, -0.57 to -0.17) and the rate ratio was 0.67 (95% CI, 0.50 to 0.84). DISCUSSION: These findings highlight the possible substantial benefits of reducing air pollution in the prevention of dementia. | |
| dc.description.sponsorship | Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé - ANR-07-LVIE-0003 | en_US |
| dc.description.sponsorship | ABSINTE : Etude fonctionnelle de l'absorption intestinale de micronutriments liposolubles : régulation et interaction - ANR-06-PNRA-0001 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Air pollution | |
| dc.subject.en | Causal inference | |
| dc.subject.en | Dementia | |
| dc.subject.en | G-formula | |
| dc.subject.en | Particulate matter | |
| dc.title.en | Air quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g‐computation | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/alz.12606 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35142029 | en_US |
| bordeaux.journal | Alzheimer’s and Dementia | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer%E2%80%99s%20and%20Dementia&rft.date=2022-02-09&rft.eissn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.issn=1552-5279%20(Electronic)%201552-5260%20(Linking)&rft.au=LETELLIER,%20Noemie&GUTIERREZ,%20Laure%E2%80%90Anne&DUCHESNE,%20Jeanne&CHEN,%20Chen&ILANGO,%20Sindana&rft.genre=article |
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