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dc.rights.licenseopenen_US
dc.contributor.authorLETELLIER, Noemie
dc.contributor.authorGUTIERREZ, Laure‐Anne
dc.contributor.authorDUCHESNE, Jeanne
dc.contributor.authorCHEN, Chen
dc.contributor.authorILANGO, Sindana
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorBERR, Claudine
dc.contributor.authorMORTAMAIS, Marion
dc.contributor.authorBENMARHNIA, Tarik
dc.date.accessioned2022-03-11T14:27:42Z
dc.date.available2022-03-11T14:27:42Z
dc.date.issued2022-02-09
dc.identifier.issn1552-5279 (Electronic) 1552-5260 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136446
dc.description.abstractEnINTRODUCTION: No evidence exists about the impact of air pollution reduction on incidence of dementia. The aim of this study was to quantify how air quality improvement leads to dementia-incidence benefits. METHODS: In the French Three-City cohort (12 years of follow-up), we used parametric g-computation to quantify the expected number of prevented dementia cases under different hypothetical interventions with particulate matter measuring <2.5 mum (PM2.5 ) reductions. RESULTS: Among 7051 participants, 789 participants developed dementia. The median PM2.5 reduction between 1990 and 2000 was 12.2 (mug/m(3) ). Such a reduction reduced the risk of all-cause dementia (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.76 to 0.95). If all study participants were enjoying a hypothetical reduction of more than 13.10 mug/m(3) (median reduction observed in the city of Montpellier), the rate difference was -0.37 (95% CI, -0.57 to -0.17) and the rate ratio was 0.67 (95% CI, 0.50 to 0.84). DISCUSSION: These findings highlight the possible substantial benefits of reducing air pollution in the prevention of dementia.
dc.description.sponsorshipHistoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgéen_US
dc.description.sponsorshipABSINTE : Etude fonctionnelle de l'absorption intestinale de micronutriments liposolubles : régulation et interaction - ANR-06-PNRA-0001en_US
dc.language.isoENen_US
dc.subject.enAir pollution
dc.subject.enCausal inference
dc.subject.enDementia
dc.subject.enG-formula
dc.subject.enParticulate matter
dc.title.enAir quality improvement and incident dementia: Effects of observed and hypothetical reductions in air pollutant using parametric g‐computation
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/alz.12606en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35142029en_US
bordeaux.journalAlzheimer’s and Dementiaen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Alzheimer%E2%80%99s%20and%20Dementia&amp;rft.date=2022-02-09&amp;rft.eissn=1552-5279%20(Electronic)%201552-5260%20(Linking)&amp;rft.issn=1552-5279%20(Electronic)%201552-5260%20(Linking)&amp;rft.au=LETELLIER,%20Noemie&amp;GUTIERREZ,%20Laure%E2%80%90Anne&amp;DUCHESNE,%20Jeanne&amp;CHEN,%20Chen&amp;ILANGO,%20Sindana&amp;rft.genre=article


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