Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LARRIEU, Thomas | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | HILAL, M L | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | FOURRIER, Celia | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | SANS, Nathalie | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | CAPURON, Lucile | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LAYE, Sophie
ORCID: 0000-0002-3843-1012 IDREF: 11366883X | |
| dc.date.accessioned | 2022-03-09T14:08:27Z | |
| dc.date.available | 2022-03-09T14:08:27Z | |
| dc.date.issued | 2014-09-09 | |
| dc.identifier.issn | 2158-3188 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/136403 | |
| dc.description.abstractEn | Understanding how malnutrition contributes to depression is building momentum. In the present study we unravel molecular and cellular mechanisms by which nutritional disturbances lead to impaired emotional behaviour in mice. Here we report that nutritional n-3 polyunsaturated fatty acids (PUFA) deficiency induces a chronic stress state reflected by disrupted glucocorticoid receptor (GR)-mediated signalling pathway along with hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. This hyperactivity in turn resulted in neuronal atrophy in the dorsolateral (dl)- and dorsomedial (dm)- prefrontal cortex (PFC) and subsequent mood-related behaviour alterations, similarly to chronic social defeat stress. Supplementation of n-3 PUFA prevented detrimental chronic social defeat stress-induced emotional and neuronal impairments by impeding HPA axis hyperactivity. These results indicate a role for dietary n-3 PUFA in the prevention of HPA axis dysfunction associated with the development of some neuropsychiatric disorders including depression. | |
| dc.description.sponsorship | Dépression et Nutrition - ANR-12-BSV4-0025 | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Depression | |
| dc.subject.en | Disease Models | |
| dc.subject.en | Animal | |
| dc.subject.en | Dominance-Subordination | |
| dc.subject.en | Emotions | |
| dc.subject.en | Fatty Acids | |
| dc.subject.en | Omega-3 | |
| dc.subject.en | Hypothalamo-Hypophyseal System | |
| dc.subject.en | Male | |
| dc.subject.en | Mice | |
| dc.subject.en | Mice | |
| dc.subject.en | Inbred C57BL | |
| dc.subject.en | Neurons | |
| dc.subject.en | Pituitary-Adrenal System | |
| dc.subject.en | Prefrontal Cortex | |
| dc.subject.en | Receptors | |
| dc.subject.en | Glucocorticoid | |
| dc.subject.en | Signal Transduction | |
| dc.title.en | Nutritional omega-3 modulates neuronal morphology in the prefrontal cortex along with depression-related behaviour through corticosterone secretion. | |
| dc.title.alternative | Transl Psychiatry | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/tp.2014.77 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 25203168 | en_US |
| bordeaux.journal | Translational Psychiatry | en_US |
| bordeaux.page | e437 | en_US |
| bordeaux.volume | 4 | en_US |
| bordeaux.hal.laboratories | NutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Recherche Agronomique | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Translational%20Psychiatry&rft.date=2014-09-09&rft.volume=4&rft.spage=e437&rft.epage=e437&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=LARRIEU,%20Thomas&HILAL,%20M%20L&FOURRIER,%20Celia&DE%20SMEDT-PEYRUSSE,%20Veronique&SANS,%20Nathalie&rft.genre=article |
