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The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.
| dc.contributor.author | DEIWICK, Jörg | |
| hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
| dc.contributor.author | SALCEDO, Suzana P | |
| hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
| dc.contributor.author | BOUCROT, Emmanuel | |
| dc.contributor.author | GILLILAND, Sarah M | |
| hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
| dc.contributor.author | HENRY, Thomas | |
| dc.contributor.author | PETERMANN, Nele | |
| dc.contributor.author | WATERMAN, Scott R | |
| hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
| dc.contributor.author | GORVEL, Jean-Pierre | |
| dc.contributor.author | HOLDEN, David W | |
| hal.structure.identifier | Centre d'Immunologie de Marseille - Luminy [CIML] | |
| dc.contributor.author | MÉRESSE, Stéphane | |
| dc.date.issued | 2006-12 | |
| dc.identifier.issn | 0019-9567 | |
| dc.description.abstractEn | The facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximity to the Golgi apparatus. Among the effector proteins translocated by the Salmonella pathogenicity island 2-encoded type III secretion system, SifA and SseG have been shown necessary but not sufficient to ensure the intracellular positioning of Salmonella vacuoles. Hence, we have investigated the involvement of other secreted effector proteins in this process. Here we show that SseF interacts functionally and physically with SseG but not SifA and is also required for the perinuclear localization of Salmonella vacuoles. The observations show that the intracellular positioning of Salmonella vacuoles is a complex phenomenon resulting from the combined action of several effector proteins. | |
| dc.language.iso | en | |
| dc.publisher | American Society for Microbiology | |
| dc.subject.mesh | Animals | |
| dc.subject.mesh | Bacterial Proteins | |
| dc.subject.mesh | Salmonella enterica | |
| dc.subject.mesh | Vacuoles | |
| dc.subject.mesh | Cells, Cultured | |
| dc.subject.mesh | Golgi Apparatus | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Mice | |
| dc.subject.mesh | Mice, Inbred Strains | |
| dc.subject.mesh | Protein Interaction Mapping | |
| dc.subject.mesh | Protein Structure, Tertiary | |
| dc.subject.mesh | Protein Transport | |
| dc.title.en | The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1128/IAI.00648-06 | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | |
| bordeaux.journal | Infection and Immunity | |
| bordeaux.page | 6965-72 | |
| bordeaux.volume | 74 | |
| bordeaux.issue | 12 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00165607 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00165607v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Infection%20and%20Immunity&rft.date=2006-12&rft.volume=74&rft.issue=12&rft.spage=6965-72&rft.epage=6965-72&rft.eissn=0019-9567&rft.issn=0019-9567&rft.au=DEIWICK,%20J%C3%B6rg&SALCEDO,%20Suzana%20P&BOUCROT,%20Emmanuel&GILLILAND,%20Sarah%20M&HENRY,%20Thomas&rft.genre=article |
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