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dc.rights.licenseopenen_US
dc.contributor.authorTORRISI, Sebastiano A.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLAVANCO, Gianluca
dc.contributor.authorMAUREL, Oriana M.
dc.contributor.authorGULISANO, Walter
dc.contributor.authorLAUDANI, Samuele
dc.contributor.authorGERACI, Federica
dc.contributor.authorGRASSO, Margherita
dc.contributor.authorBARBAGALLO, Cristina
dc.contributor.authorCARACI, Filippo
dc.contributor.authorBUCOLO, Claudio
dc.contributor.authorRAGUSA, Marco
dc.contributor.authorPAPALEO, Francesco
dc.contributor.authorCAMPOLONGO, Patrizia
dc.contributor.authorPUZZO, Daniela
dc.contributor.authorDRAGO, Filippo
dc.contributor.authorSALOMONE, Salvatore
dc.contributor.authorLEGGIO, Gian Marco
dc.date.accessioned2022-03-04T10:57:38Z
dc.date.available2022-03-04T10:57:38Z
dc.date.issued2021-05
dc.identifier.issn2352-2895en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/128827
dc.description.abstractEnTranslational animal models for studying post-traumatic stress disorder (PTSD) are valuable for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These models should encompass crucial features, including persistence of PTSD-like phenotypes triggered after exposure to a single traumatic event, trauma susceptibility/resilience and predictive validity. Here we propose a novel arousal-based individual screening (AIS) model that recapitulates all these features. The AIS model was designed by coupling the traumatization (24 h restraint) of C57BL/6 J mice with a novel individual screening. This screening consists of z-normalization of post-trauma changes in startle reactivity, which is a measure of arousal depending on neural circuits conserved across mammals. Through the AIS model, we identified susceptible mice showing long-lasting hyperarousal (up to 56 days post-trauma), and resilient mice showing normal arousal. Susceptible mice further showed persistent PTSD-like phenotypes including exaggerated fear reactivity and avoidance of trauma-related cue (up to 75 days post-trauma), increased avoidance-like behavior and social/cognitive impairment. Conversely, resilient mice adopted active coping strategies, behaving like control mice. We further uncovered novel transcriptional signatures driven by PTSD-related genes as well as dysfunction of hypothalamic–pituitary–adrenal axis, which corroborated the segregation in susceptible/resilient subpopulations obtained through the AIS model and correlated with trauma susceptibility/resilience. Impaired hippocampal synaptic plasticity was also observed in susceptible mice. Finally, chronic treatment with paroxetine ameliorated the PTSD-like phenotypes of susceptible mice. These findings indicate that the AIS model might be a new translational animal model for the study of crucial features of PTSD. It might shed light on the unclear PTSD neurobiology and identify new pharmacological targets for this difficult-to-treat disorder.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAnimal model
dc.subject.enFear conditioning
dc.subject.enResilience
dc.subject.enStress
dc.subject.enSusceptibility
dc.subject.enZ-score
dc.title.enA novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice
dc.title.alternativeNeurobiol Stressen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ynstr.2020.100286en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33392367en_US
bordeaux.journalNeurobiology of Stressen_US
bordeaux.volume14en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversità di Cataniaen_US
bordeaux.identifier.funderIDMinistero dell’Istruzione, dell’Università e della Ricercaen_US
hal.identifierhal-03597540
hal.version1
hal.date.transferred2022-03-04T10:57:42Z
hal.exporttrue
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neurobiology%20of%20Stress&rft.date=2021-05&rft.volume=14&rft.eissn=2352-2895&rft.issn=2352-2895&rft.au=TORRISI,%20Sebastiano%20A.&LAVANCO,%20Gianluca&MAUREL,%20Oriana%20M.&GULISANO,%20Walter&LAUDANI,%20Samuele&rft.genre=article


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