| dc.rights.license | open | en_US |
| dc.contributor.author | CAVAILLES, Clemence | |
| dc.contributor.author | BERR, Claudine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| dc.contributor.author | GABELLE, Audrey | |
| dc.contributor.author | JAUSSENT, Isabelle | |
| dc.contributor.author | DAUVILLIERS, Yves | |
| dc.date.accessioned | 2022-03-04T09:53:34Z | |
| dc.date.available | 2022-03-04T09:53:34Z | |
| dc.date.issued | 2022-01-20 | |
| dc.identifier.issn | 1758-9193 (Electronic) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/128825 | |
| dc.description.abstractEn | BACKGROUND: Sleep disturbances are common in elderly and occur frequently in dementia. The impact of excessive daytime sleepiness (EDS), insomnia complaints, sleep quality, and hypnotics on the risk of all-cause dementia, Alzheimer disease (AD), and dementia with vascular component (DVC) remains unclear, as does the association between sleep profile and plasma β-amyloid levels. METHODS: Analyses were carried out on 6851 participants aged 65 years and over randomly recruited from three French cities and free of dementia at baseline. A structured interview and self-questionnaire assessed sleep complaints (EDS, insomnia complaints, sleep quality) and medications at baseline. Incident cases of dementia were diagnosed systematically over a 12-year period. Multivariate Cox models were used to estimate the risk of dementia associated with the sleep complaints considered individually and globally. Plasma β-amyloid levels were measured by an xMAP-based assay technology in 984 subjects. RESULTS: After adjustment for socio-demographic characteristics, lifestyle, APOE-ε4, cardiovascular factors, and depressive status, EDS had a higher risk of all-cause dementia (HR = 1.21; 95%CI = [1.01-1.46]) and DVC (HR = 1.58; 95%CI = [1.07-2.32]) but not AD. Persistent use of hypnotics increased the risk for all-cause dementia, specifically AD (HR = 1.28; 95%CI = [1.04-1.58]), but not DVC. No association was found for insomnia complaints and sleep quality taken as individual factors or combined with EDS on the risk of dementia. No association was found between β-amyloid, sleep complaints, and incident dementia. CONCLUSIONS: The results suggest a deleterious role of EDS and hypnotics on dementia. Further studies are required to elucidate the mechanisms involved in these associations and whether its management can prevent the risk of dementia. | |
| dc.description.sponsorship | Interaction entre la vulnérabilité génétique, la dysrégulation biologique et le stress dans la dépression du sujet âgé | en_US |
| dc.description.sponsorship | COGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Sleepiness | |
| dc.subject.en | Hypnotic use | |
| dc.subject.en | Insomnia complaints | |
| dc.subject.en | Dementia | |
| dc.subject.en | Alzheimer | |
| dc.subject.en | Elderly | |
| dc.subject.en | Cohort studies | |
| dc.subject.en | Epidemiology | |
| dc.title.en | Complaints of daytime sleepiness, insomnia, hypnotic use, and risk of dementia: a prospective cohort study in the elderly | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1186/s13195-021-00952-y | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35057850 | en_US |
| bordeaux.journal | Alzheimer's Research and Therapy | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Agence Française de Sécurité Sanitaire des Produits de Santé | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
| bordeaux.identifier.funderID | Conseil Régional Languedoc-Roussillon | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.identifier | hal-03597282 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-03-04T09:53:38Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20Research%20and%20Therapy&rft.date=2022-01-20&rft.volume=14&rft.issue=1&rft.eissn=1758-9193%20(Electronic)&rft.issn=1758-9193%20(Electronic)&rft.au=CAVAILLES,%20Clemence&BERR,%20Claudine&HELMER,%20Catherine&GABELLE,%20Audrey&JAUSSENT,%20Isabelle&rft.genre=article | |
