Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats
| dc.rights.license | open | en_US |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | MARIE, Anaïs | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | LEROY, Julien | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DARRICAU, Morgane | |
| hal.structure.identifier | Institut Polytechnique de Bordeaux [Bordeaux INP] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | ALFOS, Serge | |
| hal.structure.identifier | Institut Polytechnique de Bordeaux [Bordeaux INP] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | DE SMEDT-PEYRUSSE, Veronique | |
| hal.structure.identifier | Université de Bordeaux [UB] | |
| hal.structure.identifier | CHU Bordeaux | |
| dc.contributor.author | RICHARD, Emmanuel | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| dc.contributor.author | VANCASSEL, Sylvie | |
| hal.structure.identifier | Centre interdisciplinaire de recherche en biologie [CIRB] | |
| hal.structure.identifier | Institut National de la Santé et de la Recherche Médicale [INSERM] | |
| hal.structure.identifier | University of Otago [Dunedin, Nouvelle-Zélande] | |
| hal.structure.identifier | Nutrition et Neurobiologie intégrée [NutriNeuro] | |
| hal.structure.identifier | Dynamics and Pathophysiology of Neuronal Networks Team / Dynamisme et physiopathologie des réseaux neuronaux | |
| dc.contributor.author | BOSCH BOUJU, Clementine
ORCID: 0000-0001-8869-768X IDREF: 156530244 | |
| dc.date.accessioned | 2022-03-01T16:00:24Z | |
| dc.date.available | 2022-03-01T16:00:24Z | |
| dc.date.issued | 2022-02-01 | |
| dc.identifier.issn | 2296-861X | en_US |
| dc.identifier.uri | oai:crossref.org:10.3389/fnut.2022.811843 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/128783 | |
| dc.description.abstractEn | BackgroundThe mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently investigated as a modifiable environmental factor for the prevention of PD. In particular, initial studies revealed the deleterious consequences of vitamin A signaling failure on dopamine-related motor behaviors. However, the potential of vitamin A supplementation itself to prevent neurodegeneration has not been established yet.ObjectiveThe hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.MethodsThe impact of a 5-week preventive supplementation with vitamin A (20 IU/g of diet) was measured on motor and neurobiological alterations induced by 6-hydroxydopamine (6-OHDA) unilateral injections in the striatum of rats. Rotarod, step test and cylinder tests were performed up to 3 weeks after the lesion. Post-mortem analyses (retinol and monoamines dosages, western blots, immunofluorescence) were performed to investigate neurobiological processes.ResultsVitamin A supplementation improved voluntary movements in the cylinder test. In 6-OHDA lesioned rats, a marked decrease of dopamine levels in striatum homogenates was measured. Tyrosine hydroxylase labeling in the SNc and in the striatum was significantly decreased by 6-OHDA injection, without effect of vitamin A. By contrast, vitamin A supplementation increased striatal expression of D2 and RXR receptors in the striatum of 6-OHDA lesioned rats.ConclusionsVitamin A supplementation partially alleviates motor alterations and improved striatal function, revealing a possible beneficial preventive approach for PD. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.source | crossref | |
| dc.subject.en | vitamin A | |
| dc.subject.en | dopamine | |
| dc.subject.en | Parkinson’s disease | |
| dc.subject.en | 6-hydroxydopamine (6-OHDA) | |
| dc.subject.en | aldehyde dehydrogenase ALDH1A1 | |
| dc.subject.en | substantia nigra pars compacta (SNc) | |
| dc.subject.en | striatum | |
| dc.title.en | Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fnut.2022.811843 | en_US |
| dc.subject.hal | Sciences de l'Homme et Société/Psychologie | en_US |
| bordeaux.journal | Frontiers in nutrition | en_US |
| bordeaux.volume | 9 | en_US |
| bordeaux.hal.laboratories | Laboratoire de psychology | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.identifier | hal-03593137 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-03-01T16:00:30Z | |
| hal.export | true | |
| workflow.import.source | dissemin | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20nutrition&rft.date=2022-02-01&rft.volume=9&rft.eissn=2296-861X&rft.issn=2296-861X&rft.au=MARIE,%20Ana%C3%AFs&LEROY,%20Julien&DARRICAU,%20Morgane&ALFOS,%20Serge&DE%20SMEDT-PEYRUSSE,%20Veronique&rft.genre=article |
