Preventive Vitamin A Supplementation Improves Striatal Function in 6-Hydroxydopamine Hemiparkinsonian Rats
DARRICAU, Morgane
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Nutrition et Neurobiologie intégrée [NutriNeuro]
See more >
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Nutrition et Neurobiologie intégrée [NutriNeuro]
DARRICAU, Morgane
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Institut des Maladies Neurodégénératives [Bordeaux] [IMN]
Nutrition et Neurobiologie intégrée [NutriNeuro]
ALFOS, Serge
Institut Polytechnique de Bordeaux [Bordeaux INP]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Institut Polytechnique de Bordeaux [Bordeaux INP]
Nutrition et Neurobiologie intégrée [NutriNeuro]
DE SMEDT-PEYRUSSE, Veronique
Institut Polytechnique de Bordeaux [Bordeaux INP]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Institut Polytechnique de Bordeaux [Bordeaux INP]
Nutrition et Neurobiologie intégrée [NutriNeuro]
BOSCH BOUJU, Clementine![](/themes/Mirage2//images/PERSO.svg)
Centre interdisciplinaire de recherche en biologie [CIRB]
Institut National de la Santé et de la Recherche Médicale [INSERM]
University of Otago [Dunedin, Nouvelle-Zélande]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Dynamics and Pathophysiology of Neuronal Networks Team / Dynamisme et physiopathologie des réseaux neuronaux
< Reduce
![cc](/themes/Mirage2//images/orcid_icon.png)
Centre interdisciplinaire de recherche en biologie [CIRB]
Institut National de la Santé et de la Recherche Médicale [INSERM]
University of Otago [Dunedin, Nouvelle-Zélande]
Nutrition et Neurobiologie intégrée [NutriNeuro]
Dynamics and Pathophysiology of Neuronal Networks Team / Dynamisme et physiopathologie des réseaux neuronaux
Language
EN
Article de revue
This item was published in
Frontiers in nutrition. 2022-02-01, vol. 9
English Abstract
BackgroundThe mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently ...Read more >
BackgroundThe mechanisms leading to a loss of dopaminergic (DA) neurons from the substantia nigra pars compacta (SNc) in Parkinson's disease (PD) have multifactorial origins. In this context, nutrition is currently investigated as a modifiable environmental factor for the prevention of PD. In particular, initial studies revealed the deleterious consequences of vitamin A signaling failure on dopamine-related motor behaviors. However, the potential of vitamin A supplementation itself to prevent neurodegeneration has not been established yet.ObjectiveThe hypothesis tested in this study is that preventive vitamin A supplementation can protect DA neurons in a rat model of PD.MethodsThe impact of a 5-week preventive supplementation with vitamin A (20 IU/g of diet) was measured on motor and neurobiological alterations induced by 6-hydroxydopamine (6-OHDA) unilateral injections in the striatum of rats. Rotarod, step test and cylinder tests were performed up to 3 weeks after the lesion. Post-mortem analyses (retinol and monoamines dosages, western blots, immunofluorescence) were performed to investigate neurobiological processes.ResultsVitamin A supplementation improved voluntary movements in the cylinder test. In 6-OHDA lesioned rats, a marked decrease of dopamine levels in striatum homogenates was measured. Tyrosine hydroxylase labeling in the SNc and in the striatum was significantly decreased by 6-OHDA injection, without effect of vitamin A. By contrast, vitamin A supplementation increased striatal expression of D2 and RXR receptors in the striatum of 6-OHDA lesioned rats.ConclusionsVitamin A supplementation partially alleviates motor alterations and improved striatal function, revealing a possible beneficial preventive approach for PD.Read less <
English Keywords
vitamin A
dopamine
Parkinson’s disease
6-hydroxydopamine (6-OHDA)
aldehyde dehydrogenase ALDH1A1
substantia nigra pars compacta (SNc)
striatum