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Preemptive Kidney Transplantation Is Associated With Transplantation Outcomes in Children: Results From the French Kidney Replacement Therapy Registry.

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPREZELIN-REYDIT, Mathilde
dc.contributor.authorMADDEN, Iona
dc.contributor.authorMACHER, Marie-Alice
dc.contributor.authorSALOMON, Remi
dc.contributor.authorSELLIER-LECLERC, Anne-Laure
dc.contributor.authorROUSSEY, Gwenaelle
dc.contributor.authorLAHOCHE, Annie
dc.contributor.authorGARAIX, Florentine
dc.contributor.authorDECRAMER, Stephane
dc.contributor.authorULINSKI, Tim
dc.contributor.authorFILA, Marc
dc.contributor.authorDUNAND, Olivier
dc.contributor.authorMERIEAU, Elodie
dc.contributor.authorPONGAS, Marios
dc.contributor.authorZALOSZYC, Ariane
dc.contributor.authorBAUDOUIN, Veronique
dc.contributor.authorBERARD, Etienne
dc.contributor.authorCOUCHOUD, Cecile
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHARAMBAT, Jerome
dc.date.accessioned2022-02-09T15:35:21Z
dc.date.available2022-02-09T15:35:21Z
dc.date.issued2022-02
dc.identifier.issn1534-6080en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124691
dc.description.abstractEnKidney transplantation (KT) is the optimal treatment for children with end-stage kidney disease. The aim of this study was to evaluate the impact of preemptive kidney transplantation (PKT) and of pretransplant dialysis duration on graft survival among French pediatric kidney transplant recipients. We analyzed all first pediatric kidney-only transplantations performed in France between 1993 and 2012. A Cox multivariable model was used to investigate the association of PKT and pretransplant dialysis time with the hazard of graft failure defined as death, return to dialysis, or retransplant, whichever occurred first. Patients (n = 1911) were included, of which 380 (19.8%) received a PKT. Median time of follow-up was 7.0 y. PKT was associated with a 55% reduction of the hazard of graft failure at any time after KT compared with patients transplanted after dialysis (hazard ratio, 0.45; 95% confidence interval, 0.33-0.62), after adjustment for recipient sex and age, primary kidney disease, donor age and type (living or deceased donor), number of HLA mismatches, cold ischemia time, and year of transplantation. A reduction of the hazard of graft failure was found in PKT whatever the compared duration of dialysis, even when <6 mo and whatever the dialysis modality. Results were similar in multiple sensitivity analyses. In France, PKT among pediatric patients is associated with a better graft survival when compared with KT after dialysis, even when <6 mo. Based on these findings, we suggest that PKT should be considered as the treatment of choice for children with end-stage kidney disease.
dc.language.isoENen_US
dc.title.enPreemptive Kidney Transplantation Is Associated With Transplantation Outcomes in Children: Results From the French Kidney Replacement Therapy Registry.
dc.title.alternativeTransplantationen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/TP.0000000000003757en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
dc.identifier.pubmed33821599en_US
bordeaux.journalTransplantationen_US
bordeaux.page401-411en_US
bordeaux.volume106en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03274563
hal.version1
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Transplantation&amp;rft.date=2022-02&amp;rft.volume=106&amp;rft.issue=2&amp;rft.spage=401-411&amp;rft.epage=401-411&amp;rft.eissn=1534-6080&amp;rft.issn=1534-6080&amp;rft.au=PREZELIN-REYDIT,%20Mathilde&amp;MADDEN,%20Iona&amp;MACHER,%20Marie-Alice&amp;SALOMON,%20Remi&amp;SELLIER-LECLERC,%20Anne-Laure&amp;rft.genre=article


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