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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorKOEHL, Muriel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLADEVEZE, Elodie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCATANIA, Caterina
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorABROUS, Djoher Nora
dc.date.accessioned2022-02-01T15:17:02Z
dc.date.available2022-02-01T15:17:02Z
dc.date.issued2021-03-15
dc.identifier.issn2158-3188en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124642
dc.description.abstractEnThe mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR pathway is classically involved in neurodegenerative disorders, and it has been linked to dysregulation of cognitive functions and affective states. However, information concerning the specific involvement of the p70 S6 kinase 1 (S6K1), a downstream target of the mTORC1 pathway, in learning and memory processes and in the regulation of affective states remains scant. To fill this gap, we exposed adult male mice lacking S6K1 to a battery of behavioral tests aimed at measuring their learning and memory capabilities by evaluating reference memory and flexibility with the Morris water maze, and associative memory using the contextual fear conditioning task. We also studied their anxiety-like and depression-like behaviors by, respectively, performing elevated plus maze, open field, light-dark emergence tests, and sucrose preference and forced swim tests. We found that deleting S6K1 leads to a robust anxious phenotype concomitant with associative learning deficits; these symptoms are associated with a reduction of adult neurogenesis and neuronal atrophy in the hippocampus. Collectively, these results provide grounds for the understanding of anxiety reports after treatments with mTOR inhibitors and will be critical for developing novel compounds targeting anxiety.
dc.description.sponsorshipLe rôle de la voie mTORC1 dans la modulation de la neurogenèse adulte et de la neuroinflammation hypothalamiques dans l'obésité alimentaire. - ANR-10-BLAN-1414en_US
dc.description.sponsorshipBordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.titleInhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice
dc.title.alternativeTransl Psychiatryen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41398-020-01187-5en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33723223en_US
dc.description.sponsorshipEurope3221170en_US
bordeaux.journalTranslational psychiatryen_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.title=Inhibition%20of%20mTOR%20signaling%20by%20genetic%20removal%20of%20p70%20S6%20kinase%201%20increases%20anxiety-like%20behavior%20in%20mice&rft.atitle=Inhibition%20of%20mTOR%20signaling%20by%20genetic%20removal%20of%20p70%20S6%20kinase%201%20increases%20anxiety-like%20behavior%20in%20mice&rft.jtitle=Translational%20psychiatry&rft.date=2021-03-15&rft.volume=11&rft.issue=1&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=KOEHL,%20Muriel&LADEVEZE,%20Elodie&CATANIA,%20Caterina&COTA,%20Daniela&ABROUS,%20Djoher%20Nora&rft.genre=article


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