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Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice
| dc.rights.license | open | en_US |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | KOEHL, Muriel | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | LADEVEZE, Elodie | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | CATANIA, Caterina | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | COTA, Daniela | |
| hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
| dc.contributor.author | ABROUS, Djoher Nora | |
| dc.date.accessioned | 2022-02-01T15:17:02Z | |
| dc.date.available | 2022-02-01T15:17:02Z | |
| dc.date.issued | 2021-03-15 | |
| dc.identifier.issn | 2158-3188 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124642 | |
| dc.description.abstractEn | The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR pathway is classically involved in neurodegenerative disorders, and it has been linked to dysregulation of cognitive functions and affective states. However, information concerning the specific involvement of the p70 S6 kinase 1 (S6K1), a downstream target of the mTORC1 pathway, in learning and memory processes and in the regulation of affective states remains scant. To fill this gap, we exposed adult male mice lacking S6K1 to a battery of behavioral tests aimed at measuring their learning and memory capabilities by evaluating reference memory and flexibility with the Morris water maze, and associative memory using the contextual fear conditioning task. We also studied their anxiety-like and depression-like behaviors by, respectively, performing elevated plus maze, open field, light-dark emergence tests, and sucrose preference and forced swim tests. We found that deleting S6K1 leads to a robust anxious phenotype concomitant with associative learning deficits; these symptoms are associated with a reduction of adult neurogenesis and neuronal atrophy in the hippocampus. Collectively, these results provide grounds for the understanding of anxiety reports after treatments with mTOR inhibitors and will be critical for developing novel compounds targeting anxiety. | |
| dc.description.sponsorship | Le rôle de la voie mTORC1 dans la modulation de la neurogenèse adulte et de la neuroinflammation hypothalamiques dans l'obésité alimentaire. - ANR-10-BLAN-1414 | en_US |
| dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.title | Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice | |
| dc.title.alternative | Transl Psychiatry | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1038/s41398-020-01187-5 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
| dc.identifier.pubmed | 33723223 | en_US |
| dc.description.sponsorshipEurope | 3221170 | en_US |
| bordeaux.journal | Translational psychiatry | en_US |
| bordeaux.volume | 11 | en_US |
| bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Centre National de la Recherche Scientifique | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.title=Inhibition%20of%20mTOR%20signaling%20by%20genetic%20removal%20of%20p70%20S6%20kinase%201%20increases%20anxiety-like%20behavior%20in%20mice&rft.atitle=Inhibition%20of%20mTOR%20signaling%20by%20genetic%20removal%20of%20p70%20S6%20kinase%201%20increases%20anxiety-like%20behavior%20in%20mice&rft.jtitle=Translational%20psychiatry&rft.date=2021-03-15&rft.volume=11&rft.issue=1&rft.eissn=2158-3188&rft.issn=2158-3188&rft.au=KOEHL,%20Muriel&LADEVEZE,%20Elodie&CATANIA,%20Caterina&COTA,%20Daniela&ABROUS,%20Djoher%20Nora&rft.genre=article |
