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Global Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults: A Worldwide Meta-analysis: The GOAL-Initiative

dc.rights.licenseopenen_US
dc.contributor.authorJACOB, Mina A.
dc.contributor.authorEKKER, Merel S.
dc.contributor.authorALLACH, Youssra
dc.contributor.authorCAI, Mengfei
dc.contributor.authorAARNIO, Karoliina
dc.contributor.authorARAUZ, Antonio
dc.contributor.authorARNOLD, Marcel
dc.contributor.authorBAE, Hee Joon
dc.contributor.authorBANDEO, Lucrecia
dc.contributor.authorBARBOZA, Miguel A.
dc.contributor.authorBOLOGNESE, Manuel
dc.contributor.authorBONARDO, Pablo
dc.contributor.authorBROUNS, Raf
dc.contributor.authorCHULUUN, Batnairamdal
dc.contributor.authorCHULUUNBATAR, Enkhzaya
dc.contributor.authorCORDONNIER, Charlotte
dc.contributor.authorDAGVAJANTSAN, Byambasuren
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDON, Adi
dc.contributor.authorENZINGER, Chris
dc.contributor.authorEKIZOGLU, Esme
dc.contributor.authorFANDLER-HOFLER, Simon
dc.contributor.authorFAZEKAS, Franz
dc.contributor.authorFROMM, Annette
dc.contributor.authorGATTRINGER, Thomas
dc.contributor.authorHORA, Thiago F.
dc.contributor.authorJERN, Christina
dc.contributor.authorJOOD, Katarina
dc.contributor.authorSEO, Kim Young
dc.contributor.authorKITTNER, Steven
dc.contributor.authorKLEINIG, Timothy
dc.contributor.authorKLIJN, Catharina J. M.
dc.contributor.authorKORV, Janika
dc.contributor.authorKUMAR, Vinod
dc.contributor.authorLEE, Keon Joo
dc.contributor.authorLEE, Tsong Hai
dc.contributor.authorMAAIJWEE, Noortje A. M.
dc.contributor.authorMARTINEZ-MAJANDER, Nicolas
dc.contributor.authorMARTO, Joao P.
dc.contributor.authorMEHNDIRATTA, Man M.
dc.contributor.authorMIFSUD, Victoria
dc.contributor.authorMONTANARO, Vinicius
dc.contributor.authorPACIO, Gisele
dc.contributor.authorPATEL, Vinod B.
dc.contributor.authorPHILLIPS, Matthew C.
dc.contributor.authorPIECHOWSKI-JOZWIAK, Bartlomiej
dc.contributor.authorPIKULA, Aleksandra
dc.contributor.authorRUIZ-SANDOVAL, Jose
dc.contributor.authorVON SARNOWSKI, Bettina
dc.contributor.authorSWARTZ, Richard H.
dc.contributor.authorTAN, Kay Sin
dc.contributor.authorTANNE, David
dc.contributor.authorTATLISUMAK, Turgut
dc.contributor.authorTHIJS, Vincent
dc.contributor.authorVIANA-BAPTISTA, Miguel
dc.contributor.authorVIBO, Riina
dc.contributor.authorWU, Teddy Y.
dc.contributor.authorYESILOT, Nilufer
dc.contributor.authorWAJE-ANDREASSEN, Ulrike
dc.contributor.authorPEZZINI, Alessandro
dc.contributor.authorPUTAALA, Jukka
dc.contributor.authorTULADHAR, Anil M.
dc.contributor.authorLEEUW, Frank Erik De
dc.date.accessioned2022-01-19T16:09:07Z
dc.date.available2022-01-19T16:09:07Z
dc.date.issued2021-12-14
dc.identifier.issn1526-632X (Electronic) 0028-3878 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124441
dc.description.abstractEnBACKGROUND AND OBJECTIVES: There is a worldwide increase in the incidence of stroke in young adults, with major regional and ethnic differences. Advancing knowledge of ethnic and regional variation in causes and outcomes will be beneficial in implementation of regional healthcare services. To study the global distribution of risk factors, causes and 3-month mortality of young ischemic stroke patients, by performing a patient data meta-analysis form different cohorts worldwide. METHODS: We did a pooled analysis of individual patient data from cohort studies which included consecutive ischemic stroke patients aged 18-50 years. We studied differences in prevalence of risk factors and causes between different ethnic and racial groups, geographic regions and countries with different income levels. We investigated differences in 3-month mortality by mixed-effects multivariable logistic regression. RESULTS: We included 17,663 patients from 32 cohorts in 29 countries. Hypertension and diabetes were most prevalent in Blacks (hypertension, 52.1%; diabetes, 20.7%) and Asians (hypertension 46.1%, diabetes, 20.9%). Large vessel atherosclerosis and small vessel disease were more often cause of stroke in high-income countries (HICs; both p<0.001), whereas ''other determined stroke'' and ''undetermined stroke'' were higher in low and middle-income countries (LMICs; both p<0.001). Patients in LMICs were younger, had less vascular risk factors, and despite this, more often died within 3 months than those from HICs (OR 2.49; 95% CI 1.42-4.36). DISCUSSION: The ethnoracial and regional differences in risk factors and causes of stroke at young age provide an understanding of ethnic and racial, and regional differences in incidence of ischemic stroke. Our results also visualize the dissimilarities in outcome after stroke in young adults that exist between LMICs and HICs, which should serve as call to action to improve healthcare facilities in LMICs.
dc.language.isoENen_US
dc.title.enGlobal Differences in Risk Factors, Etiology, and Outcome of Ischemic Stroke in Young Adults: A Worldwide Meta-analysis: The GOAL-Initiative
dc.typeArticle de revueen_US
dc.identifier.doi10.1212/wnl.0000000000013195en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34906974en_US
bordeaux.journalNeurologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03535665
hal.version1
hal.date.transferred2022-01-19T16:09:12Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Neurology&amp;rft.date=2021-12-14&amp;rft.eissn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.issn=1526-632X%20(Electronic)%200028-3878%20(Linking)&amp;rft.au=JACOB,%20Mina%20A.&amp;EKKER,%20Merel%20S.&amp;ALLACH,%20Youssra&amp;CAI,%20Mengfei&amp;AARNIO,%20Karoliina&amp;rft.genre=article


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