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Retrospective multicentric study on Campylobacter spp. bacteremia in France: the Campylobacteremia study

dc.rights.licenseopenen_US
dc.contributor.authorTINEVEZ, Claire
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorVELARDO, Fanny
dc.contributor.authorRANC, Anne Gaelle
dc.contributor.authorDUBOIS, Damien
dc.contributor.authorPAILHORIES, Helene
dc.contributor.authorCODDE, Cyrielle
dc.contributor.authorJOIN-LAMBERT, Olivier
dc.contributor.authorGRAS, Emmanuelle
dc.contributor.authorCORVEC, Stephane
dc.contributor.authorNEUWIRTH, Catherine
dc.contributor.authorMELENOTTE, Clea
dc.contributor.authorDOREL, Marie
dc.contributor.authorLAGNEAUX, Anne Sophie
dc.contributor.authorPICHON, Maxime
dc.contributor.authorDOAT, Violaine
dc.contributor.authorFOURNIER, Damien
dc.contributor.authorLEMAIGNEN, Adrien
dc.contributor.authorBOUARD, Leslie
dc.contributor.authorPATOZ, Pierre
dc.contributor.authorHERY-ARNAUD, Genevieve
dc.contributor.authorLEMAITRE, Nadine
dc.contributor.authorCOUZIGOU, Celia
dc.contributor.authorGUILLARD, Thomas
dc.contributor.authorRECALT, Elise
dc.contributor.authorBILLE, Emmanuelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELAROUSSI, Yaniss
dc.contributor.authorNEAU, Didier
dc.contributor.authorCAZANAVE, Charles
hal.structure.identifierBordeaux Research In Translational Oncology [Bordeaux] [BaRITOn]
dc.contributor.authorLEHOURS, Philippe
dc.contributor.authorPUGES, Mathilde
dc.contributor.authorCAMPYLOBACTEREMIA STUDY, Group
dc.date.accessioned2022-01-17T11:29:41Z
dc.date.available2022-01-17T11:29:41Z
dc.date.issued2021-11-26
dc.identifier.issn1537-6591 (Electronic) 1058-4838 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124409
dc.description.abstractEnBACKGROUND: Campylobacter spp. bacteremia is a severe infection. A nationwide 5-year retrospective study was conducted to characterize its clinical features and prognostic factors. METHODS: Patients diagnosed with Campylobacter spp. bacteremia in 37 French hospitals participating in the surveillance network of the National Reference Center for Campylobacter and Helicobacter were included from January 1, 2015, to December 31, 2019. The goal was to analyze the effects of a delay of appropriate antibiotic therapy and other risk factors on 30-day mortality, antibiotic resistance, patient characteristics and prognosis according to the Campylobacter species. FINDINGS: Among the 592 patients, Campylobacter jejuni and Campylobacter fetus were the most commonly identified species (42.9 and 42.6%, respectively). The patients were elderly (median age 68 years), and most had underlying conditions, mainly immunodepression (43.4%), hematologic malignancies (25.9%), solid neoplasms (23%) and diabetes (22.3%). C. jejuni and Campylobacter coli were associated with gastrointestinal signs, and C. fetus was associated with secondary localizations. Among the 80 patients (13.5%) with secondary localizations, 12 had endocarditis, 38 vascular, 24 osteo-articular and 9 ascitic fluid infections. The thirty-day mortality rate was 11.7%, and an appropriate antibiotic treatment was independently associated with 30-day survival (odds ratio [OR]=0.47, 95% CI [0.24-0.93], p=0.03). The median efficient therapy initiation delay was quite short (2 days, IQR [0-4]) but it had no significant impact on 30-day mortality (p=0.78). INTERPRETATION: Campylobacter spp. bacteremia mainly occurred in elderly immunocompromised individuals with variable clinical presentations according to the species involved. Appropriate antimicrobial therapy was associated with improved 30-day survival.
dc.language.isoENen_US
dc.subject.enCampylobacter spp
dc.subject.enBacteremia
dc.subject.enImmunosuppression
dc.subject.enZoonosis
dc.title.enRetrospective multicentric study on Campylobacter spp. bacteremia in France: the Campylobacteremia study
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciab983en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34849656en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2021-11-26&rft.eissn=1537-6591%20(Electronic)%201058-4838%20(Linking)&rft.issn=1537-6591%20(Electronic)%201058-4838%20(Linking)&rft.au=TINEVEZ,%20Claire&VELARDO,%20Fanny&RANC,%20Anne%20Gaelle&DUBOIS,%20Damien&PAILHORIES,%20Helene&rft.genre=article


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