SAMIERI, Cecilia; YASSINE, Hussein N.; MELO VAN LENT, Debora; LEFEVRE ARBOGAST, Sophie; VAN DE REST, Ondine; BOWMAN, Gene L.; SCARMEAS, Nikolaos

doi:10.1002/alz.12486

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SAMIERI, Cecilia

Bordeaux population health [BPH]

YASSINE, Hussein N.

MELO VAN LENT, Debora

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Alzheimer's and Dementia. 2021-11-10

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The role of nutrition has been investigated for decades under the assumption of one-size-fits-all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet-related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time-window has the potential to strengthen dementia-prevention efforts.< Leer menos

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Diet

Exposome

Individualized prevention

Nutrition

Precision medicine

Precision nutrition

Prevention

Risk factors in epidemiology

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Personalized nutrition for dementia prevention

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Centros de investigación