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dc.rights.licenseopenen_US
dc.contributor.authorCHONSUI, Moerani
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
ORCID: 0000-0003-2848-6287
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535
IDREF: 028739272
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUGIER, Marie-Benedicte
dc.date.accessioned2022-01-13T09:14:49Z
dc.date.available2022-01-13T09:14:49Z
dc.date.issued2021-10-22
dc.identifier.issn1536-5166 (Electronic) 1070-8022 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124367
dc.description.abstractEnBACKGROUND: To quantitatively compare the peripapillary microvascular network between patients with papilledema and healthy subjects using swept source optical coherence tomography angiography. METHODS: In this retrospective observational study, patients with papilledema secondary to idiopathic intracranial hypertension and healthy controls were imaged with swept source optical coherence tomography angiography (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, CA) using a 6 x 6 mm scan pattern centered on the optic disc. The capillary perfusion density (CPD) and capillary flux index (CFI) of the radial peripapillary capillaries in the retinal nerve fiber layer (RNFL) were calculated using Zeiss algorithm. RESULTS: Thirty-nine eyes of 20 patients with papilledema and 66 eyes of 33 healthy subjects were imaged. The mean (P < 0.01), superior (P < 0.01), inferior (P < 0.01), and temporal (P = 0.02) CPD significantly differed between both groups. No significant difference was found between both groups for the CFI. The mean (P < 0.01), superior (P < 0.01), inferior (P = 0.01), temporal (P < 0.01), and nasal (P < 0.01) quadrants of the RNFL were positively associated with the CFI. The mean (P < 0.01), superior (P = 0.01), inferior (P = 0.01), temporal (P < 0.01), and nasal (P = 0.01) quadrants of the RNFL were negatively associated with the CPD. CONCLUSION: Our study showed a decreased peripapillary capillary density without changes in flux intensity in eyes with papilledema. There were a positive association between the CFI and the RNFL and a negative association between the CPD and the RNFL. It confirmed the discriminatory ability of OCTA in differentiating a papilledema secondary to IIH from a normal optic disc, while providing complementary information for understanding papilledema pathophysiology.
dc.language.isoENen_US
dc.title.enQuantitative Analysis of Radial Peripapillary Capillary Network in Patients With Papilledema Compared with Healthy Subjects Using Optical Coherence Tomography Angiography
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/WNO.0000000000001460en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34860747en_US
bordeaux.journalJournal of Neuro-Ophthalmologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03524187
hal.version1
hal.date.transferred2022-01-13T09:14:50Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Journal%20of%20Neuro-Ophthalmology&amp;rft.date=2021-10-22&amp;rft.eissn=1536-5166%20(Electronic)%201070-8022%20(Linking)&amp;rft.issn=1536-5166%20(Electronic)%201070-8022%20(Linking)&amp;rft.au=CHONSUI,%20Moerani&amp;LE%20GOFF,%20Melanie&amp;KOROBELNIK,%20Jean-Francois&amp;ROUGIER,%20Marie-Benedicte&amp;rft.genre=article


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