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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDUBANET, Olivier
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFERREIRA GOMES DA SILVA, Arnaldo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFRICK, Andreas
dc.contributor.authorHIRASE, Hajime
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBEYELER, Anna
ORCID: 0000-0003-2371-5706
IDREF: 141902892
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLEINEKUGEL, Xavier
dc.date.accessioned2021-12-21T15:47:53Z
dc.date.available2021-12-21T15:47:53Z
dc.date.issued2021-07-13
dc.identifier.issn2211-1247en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124299
dc.description.abstractEnThe hypothesis that reversed, excitatory GABA may be involved in various brain pathologies, including epileptogenesis, is appealing but controversial because of the technical difficulty of probing endogenous GABAergic synaptic function in vivo. We overcome this challenge by non-invasive extracellular recording of neuronal firing responses to optogenetically evoked and spontaneously occurring inhibitory perisomatic GABAergic field potentials, generated by individual parvalbumin interneurons on their target pyramidal cells. Our direct probing of GABAergic transmission suggests a rather anecdotal participation of excitatory GABA in two specific models of epileptogenesis in the mouse CA3 circuit in vivo, even though this does not preclude its expression in other brain areas or pathological conditions. Our approach allows the detection of distinct alterations of inhibition during spontaneous activity in vivo, with high sensitivity. It represents a promising tool for the investigation of excitatory GABA in different pathological conditions that may affect the hippocampal circuit.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enEpilepsy
dc.subject.enGABAergic transmission
dc.subject.enHippocampus
dc.subject.enInhibition
dc.subject.enInterneurons
dc.title.enProbing the polarity of spontaneous perisomatic GABAergic synaptic transmission in the mouse CA3 circuit in vivo
dc.title.alternativeCell Rep.en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.celrep.2021.109381en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34260906en_US
bordeaux.journalCell Reportsen_US
bordeaux.volume36en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDCentre National de la Recherche Scientifiqueen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.identifierhal-03328694
hal.version1
hal.exporttrue
dc.rights.ccCC BY-NC-NDen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cell%20Reports&rft.date=2021-07-13&rft.volume=36&rft.issue=2&rft.eissn=2211-1247&rft.issn=2211-1247&rft.au=DUBANET,%20Olivier&FERREIRA%20GOMES%20DA%20SILVA,%20Arnaldo&FRICK,%20Andreas&HIRASE,%20Hajime&BEYELER,%20Anna&rft.genre=article


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