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Cannabinoids drugs and oral health-from recreational side-effects to medicinal purposes: a systematic review

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorINCHINGOLO, Alessio Danilo
dc.contributor.authorINCHINGOLO, Angelo Michele
dc.contributor.authorLORUSSO, Felice
dc.contributor.authorMALCANGI, Giuseppina
dc.contributor.authorSANTACROCE, Luigi
dc.contributor.authorSCARANO, Antonio
dc.contributor.authorBORDEA, Ioana Roxana
dc.contributor.authorHAZBALLA, Denisa
dc.contributor.authorD’ORIA, Maria Teresa
dc.contributor.authorISACCO, Ciro Gargiulo
dc.contributor.authorNUCCI, Ludovica
dc.contributor.authorSERPICO, Rosario
dc.contributor.authorTARTAGLIA, Gianluca Martino
dc.contributor.authorGIOVANNIELLO, Delia
dc.contributor.authorCONTALDO, Maria
dc.contributor.authorFARRONATO, Marco
dc.contributor.authorDIPALMA, Gianna
dc.contributor.authorINCHINGOLO, Francesco
dc.date.accessioned2021-12-21T15:28:14Z
dc.date.available2021-12-21T15:28:14Z
dc.date.issued2021-08-03
dc.identifier.issn1422-0067en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124296
dc.description.abstractEnBackground: Marijuana, the common name for cannabis sativa preparations, is one of the most consumed drug all over the world, both at therapeutical and recreational levels. With the legalization of medical uses of cannabis in many countries, and even its recreational use in most of these, the prevalence of marijuana use has markedly risen over the last decade. At the same time, there is also a higher prevalence in the health concerns related to cannabis use and abuse. Thus, it is mandatory for oral healthcare operators to know and deal with the consequences and effects of cannabis use on oral cavity health. This review will briefly summarize the components of cannabis and the endocannabinoid system, as well as the cellular and molecular mechanisms of biological cannabis action in human cells and biologic activities on tissues. We will also look into oropharyngeal tissue expression of cannabinoid receptors, together with a putative association of cannabis to several oral diseases. Therefore, this review will elaborate the basic biology and physiology of cannabinoids in human oral tissues with the aim of providing a better comprehension of the effects of its use and abuse on oral health, in order to include cannabinoid usage into dental patient health records as well as good medicinal practice. Methods: The paper selection was performed by PubMed/Medline and EMBASE electronic databases, and reported according to the PRISMA guidelines. The scientific products were included for qualitative analysis. Results: The paper search screened a total of 276 papers. After the initial screening and the eligibility assessment, a total of 32 articles were considered for the qualitative analysis. Conclusions: Today, cannabis consumption has been correlated to a higher risk of gingival and periodontal disease, oral infection and cancer of the oral cavity, while the physico-chemical activity has not been completely clarified. Further investigations are necessary to evaluate a therapeutic efficacy of this class of drugs for the promising treatment of several different diseases of the salivary glands and oral diseases.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCannabis
dc.subject.enMouth diseases
dc.subject.enOral health
dc.subject.enTherapeutic adjuvant
dc.title.enCannabinoids drugs and oral health-from recreational side-effects to medicinal purposes: a systematic review
dc.title.alternativeInt J Mol Scien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms22158329en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed34361095en_US
bordeaux.journalInternational Journal of Molecular Sciencesen_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue15en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03781869
hal.version1
hal.date.transferred2022-09-20T15:33:23Z
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Molecular%20Sciences&rft.date=2021-08-03&rft.volume=22&rft.issue=15&rft.eissn=1422-0067&rft.issn=1422-0067&rft.au=BELLOCCHIO,%20Luigi&INCHINGOLO,%20Alessio%20Danilo&INCHINGOLO,%20Angelo%20Michele&LORUSSO,%20Felice&MALCANGI,%20Giuseppina&rft.genre=article


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