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Hypothalamic bile acid-TGR5 signaling protects from obesity

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCASTELLANOS JANKIEWICZ, Ashley
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGUZMAN-QUEVEDO, Omar
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFENELON, Valerie S.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorZIZZARI, Philippe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorQUARTA, Carmelo
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.contributor.authorTAILLEUX, Anne
dc.contributor.authorCHARTON, Julie
dc.contributor.authorFERNANDOIS, Daniela
dc.contributor.authorHENRICSSON, Marcus
dc.contributor.authorPIVETEAU, Catherine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSIMON, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorALLARD, Camille
dc.contributor.authorQUEMENER, Sandrine
dc.contributor.authorGUINOT, Valentine
dc.contributor.authorHENNUYER, Nathalie
dc.contributor.authorPERINO, Alessia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDUVEAU, Alexia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMAITRE, Marlene
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLESTE-LASSERRE, Thierry
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCLARK, Samantha
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDUPUY, Nathalie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGONZALES, Delphine
dc.contributor.authorDEPREZ, Benoit
dc.contributor.authorMITHIEUX, Gilles
dc.contributor.authorDOMBROWICZ, David
dc.contributor.authorBACKHED, Fredrik
dc.contributor.authorPREVOT, Vincent
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
dc.contributor.authorSTAELS, Bart
dc.contributor.authorSCHOONJANS, Kristina
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCOTA, Daniela
dc.date.accessioned2021-12-21T14:16:25Z
dc.date.available2021-12-21T14:16:25Z
dc.date.issued2021-07-06
dc.identifier.issn1932-7420en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124292
dc.description.abstractEnBile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the brain hypothalamus, but whether hypothalamic BA signaling is implicated in body weight control and obesity pathophysiology remains unknown. Here we show that hypothalamic BA content is reduced in diet-induced obese mice. Central administration of BAs or a specific TGR5 agonist in these animals decreases body weight and fat mass by activating the sympathetic nervous system, thereby promoting negative energy balance. Conversely, genetic downregulation of hypothalamic TGR5 expression in the mediobasal hypothalamus favors the development of obesity and worsens established obesity by blunting sympathetic activity. Lastly, hypothalamic TGR5 signaling is required for the anti-obesity action of dietary BA supplementation. Together, these findings identify hypothalamic TGR5 signaling as a key mediator of a top-down neural mechanism that counteracts diet-induced obesity.
dc.language.isoENen_US
dc.subject.enBile acids
dc.subject.enBody weight
dc.subject.enDiet
dc.subject.enEnergy expenditure
dc.subject.enFood intake
dc.subject.enGPBAR1
dc.subject.enHypothalamus
dc.subject.enObesity
dc.subject.enSympathetic nervous system
dc.subject.enTGR5
dc.title.enHypothalamic bile acid-TGR5 signaling protects from obesity
dc.title.alternativeCell Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.cmet.2021.04.009en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33887197en_US
bordeaux.journalCell Metabolismen_US
bordeaux.page1483-1492.e10en_US
bordeaux.volume33en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierinserm-03257931
hal.version1
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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