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dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSCHOLLHAMMER, Romain
dc.contributor.authorLEPREUX, Sébastien
hal.structure.identifierBioingénierie tissulaire [BIOTIS]
dc.contributor.authorBARTHE, Nicole
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorVIMONT, Delphine
dc.contributor.authorRULLIER, Anne
dc.contributor.authorSIBON, Igor
dc.contributor.authorBERARD, Xavier
dc.contributor.authorZHANG, Andrea
dc.contributor.authorKIMURA, Yasuyuki
dc.contributor.authorFUJITA, Masahiro
dc.contributor.authorINNIS, Robert B
dc.contributor.authorZANOTTI-FREGONARA, Paolo
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMORGAT, Clement
dc.date.accessioned2021-12-21T09:06:35Z
dc.date.available2021-12-21T09:06:35Z
dc.date.issued2021-05-05
dc.identifier.issn2191-219Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124242
dc.description.abstractEnInflammatory vascular disease of the arteries, such as inflamed atheromatous plaques or arteritis, may cause aneurysms or ischemic strokes. In this context, using positron emission tomography (PET) to image inflammation may help select patients who would benefit from appropriate therapeutic interventions. This study sought to assess the usefulness of the 18 kDa translocator protein (TSPO) tracers [C]-PBR28 and [F]-PBR06 for imaging inflammatory vascular disease in vitro and in vivo. Immunohistochemistry for macrophage infiltration as well as autoradiography with [F]-PBR06 were performed on eight paraffin-embedded, formalin-fixed atherosclerosis plaques prospectively collected after carotid endarterectomy of eight patients affected by ischemic stroke. Six different patients, one of whom was also included in the in vitro study, underwent PET imaging. Two patients with carotid stenosis associated with ischemic stroke were imaged with [F]-PBR06 PET/CT, and four other patients (three with large vessel vasculitis and one with bilateral carotid stenosis but without stroke) were imaged with [C]-PBR28. All in vitro sections showed specific binding of [F]-PBR06, which co-localized with immunohistochemistry markers for inflammation. However, in vivo TSPO imaging with either [C]-PBR28 or [F]-PBR06 was negative in all participants. Despite good uptake on surgical samples in vitro, [C]-PBR28 and [F]-PBR06 are not viable clinical tools for imaging inflammatory vascular disease. NCT02513589, registered 31 July 2015 and NCT00547976, registered 23 October 2007. https://clinicaltrials.gov .
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subject.enAtherosclerosis
dc.subject.enInflammation
dc.subject.enPET/CT
dc.subject.enTSPO
dc.subject.enVasculitis
dc.title.enIn vitro and pilot in vivo imaging of 18 kDa translocator protein (TSPO) in inflammatory vascular disease.
dc.title.alternativeEJNMMI Resen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s13550-021-00786-7en_US
dc.subject.halSciences du Vivant [q-bio]/Biotechnologiesen_US
dc.identifier.pubmed33950298en_US
bordeaux.journalEJNMMI Researchen_US
bordeaux.page45en_US
bordeaux.volume11en_US
bordeaux.hal.laboratoriesBioingénierie Tissulaire (BioTis) - UMR_S 1026en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCHU de Bordeauxen_US
bordeaux.institutionInstitut Bergoniéen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-03498665
hal.version1
hal.date.transferred2021-12-21T09:07:05Z
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EJNMMI%20Research&rft.date=2021-05-05&rft.volume=11&rft.issue=1&rft.spage=45&rft.epage=45&rft.eissn=2191-219X&rft.issn=2191-219X&rft.au=SCHOLLHAMMER,%20Romain&LEPREUX,%20S%C3%A9bastien&BARTHE,%20Nicole&VIMONT,%20Delphine&RULLIER,%20Anne&rft.genre=article


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