Comparison of perfused volume segmentation between cone-beam CT and Tc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using Y-glass microspheres.
| dc.rights.license | open | en_US |
| dc.contributor.author | MARTIN, M | |
| dc.contributor.author | HOCQUELET, A | |
| dc.contributor.author | DEBORDEAUX, F | |
| hal.structure.identifier | Bioingénierie tissulaire [BIOTIS] | |
| dc.contributor.author | BORDENAVE, Laurence
IDREF: 057389675 | |
| dc.contributor.author | BLANC, J-F | |
| dc.contributor.author | PAPADOPOULOS, P | |
| dc.contributor.author | LAPUYADE, B | |
| dc.contributor.author | TRILLAUD, H | |
| dc.contributor.author | PINAQUY, J-B | |
| dc.date.accessioned | 2021-12-21T08:42:51Z | |
| dc.date.available | 2021-12-21T08:42:51Z | |
| dc.date.issued | 2021-01-01 | |
| dc.identifier.issn | 2211-5684 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124234 | |
| dc.description.abstractEn | To compare the reliability and accuracy of the pre-treatment dosimetry predictions using cone-beam computed tomography (CBCT) versus Tc-labeled macroaggregated albumin (MAA) SPECT/CT for perfused volume segmentation in patients with hepatocellular carcinoma treated by selective internal radiation therapy (SIRT) using Y-glass microspheres. Fifteen patients (8 men, 7 women) with a mean age of 68.3±10.5 (SD) years (range: 47-82 years) who underwent a total of 17 SIRT procedures using Y-glass microspheres for unresectable hepatocellular carcinoma were retrospectively included. Pre-treatment dosimetry data were calculated from Tc-MAA SPECT/CT using either CBCT or Tc-MAA SPECT/CT to segment the perfused volumes. Post-treatment dosimetry data were calculated using Y imaging (SPECT/CT or PET/CT). The whole liver, non-tumoral liver, and tumor volumes were segmented on CT or MRI data. The mean absorbed doses of the tumor (D), non-tumoral liver, perfused liver (D) and perfused non-tumoral liver were calculated. Intra- and interobserver reliabilities were investigated by calculating Lin's concordant correlation coefficients (ρ values). The differences (biases) between pre- and post-treatment dosimetry data were assessed using the modified Bland-Altman method (for non-normally distributed variables), and systematic bias was evaluated using Passing-Bablok regression. The intra- and interobserver reliabilities were good-to-excellent (ρ: 0.80-0.99) for all measures using both methods. Compared with 90Y imaging, the median differences were 5.8Gy (IQR: -12.7; 16.1) and 5.6Gy (IQR: -13.6; 10.2) for D-CBCT and D-Tc-MAA SPECT/CT, respectively. The median differences were 1.6Gy (IQR: -29; 7.53) and 9.8Gy (IQR: -28.4; 19.9) for D-CBCT and D-Tc-MAA SPECT/CT respectively. Passing-Bablok regression analysis showed that both CBCT and Tc-MAA SPECT/CT had proportional biases and thus tendencies to overestimate D and D at higher post-treatment doses. CBCT may be a reliable segmentation method, but it does not significantly increase the accuracy of dose prediction compared with that of Tc-MAA SPECT/CT. At higher doses both methods tend to overestimate the doses to tumors and perfused livers. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Aged | |
| dc.subject.en | Aged | |
| dc.subject.en | 80 and over | |
| dc.subject.en | Albumins | |
| dc.subject.en | Carcinoma | |
| dc.subject.en | Hepatocellular | |
| dc.subject.en | Cone-Beam Computed Tomography | |
| dc.subject.en | Embolization | |
| dc.subject.en | Therapeutic | |
| dc.subject.en | Female | |
| dc.subject.en | Humans | |
| dc.subject.en | Liver Neoplasms | |
| dc.subject.en | Male | |
| dc.subject.en | Microspheres | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Positron Emission Tomography Computed Tomography | |
| dc.subject.en | Reproducibility of Results | |
| dc.subject.en | Retrospective Studies | |
| dc.subject.en | Technetium Tc 99m Aggregated Albumin | |
| dc.subject.en | Tomography | |
| dc.subject.en | Emission-Computed | |
| dc.subject.en | Single-Photon | |
| dc.subject.en | Yttrium Radioisotopes | |
| dc.title.en | Comparison of perfused volume segmentation between cone-beam CT and Tc-MAA SPECT/CT for treatment dosimetry before selective internal radiation therapy using Y-glass microspheres. | |
| dc.title.alternative | Diagn Interv Imaging | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.diii.2020.09.003 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
| dc.identifier.pubmed | 33032960 | en_US |
| bordeaux.journal | Diagnostic and Interventional Imaging | en_US |
| bordeaux.page | 45-52 | en_US |
| bordeaux.volume | 102 | en_US |
| bordeaux.hal.laboratories | Bioingénierie Tissulaire (BioTis) - UMR_S 1026 | en_US |
| bordeaux.issue | 1 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.institution | Institut Bergonié | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03493594 | |
| hal.version | 1 | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diagnostic%20and%20Interventional%20Imaging&rft.date=2021-01-01&rft.volume=102&rft.issue=1&rft.spage=45-52&rft.epage=45-52&rft.eissn=2211-5684&rft.issn=2211-5684&rft.au=MARTIN,%20M&HOCQUELET,%20A&DEBORDEAUX,%20F&BORDENAVE,%20Laurence&BLANC,%20J-F&rft.genre=article |
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