KUJAWSKA, M.; JOURDES, Michael; WITUCKI, L.; KARAZNIEWICZ-LADA, M.; SZULC, M.; GORSKA, A.; MIKOLAJCZAK, P.L.; TEISSEDRE, Pierre Louis; JODYNIS-LIEBERT, J.

doi:10.3390/brainsci11091127

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

WITUCKI, L.

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Article de revue

Ce document a été publié dans

Brain sciences. 2021, vol. 11, n° 9

Résumé en anglais

Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors of colonic metabolite urolithin A, which are believed to contribute to pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. Previously, we have reported that PJ treatment improved postural stability, which correlated well with enhancement of neuronal survival, protection against oxidative damage, and ?-synuclein aggregation. Since olfactory and motor deficits are typical symptoms of PD, in this study, we aimed to investigate the capability of PJ to protect against olfactory, motoric, and neuro-chemical alterations. To evaluate its efficiency, Wistar rats were given a combined treatment with ROT (1.3 mg/kg b.w./day, s.c.) and PJ (500 mg/kg/day, p.o.) for 35 days. After this, we assessed the olfactory discrimination index (DI) and vertical and horizontal activities as well as levels of dopamine and its main metabolite 3,4-Dihydroxyphenylacetic acid (DOPAC) in the dissected midbrain of animals. Our findings provide the first evidence that PJ treatment protects against ROT-induced DA depletion in the midbrain, which correlates well with improved olfactory function and vertical activity as well as with the presence of urolithin A in the brain.< Réduire

Mots clés en anglais

Pomegranate juice

Urolithin

Ellagitannins

Dopamine

Olfactory impairment

?-synuclein

Non-motor symptoms

Motor symptoms

Parkinson’s disease

URI

https://oskar-bordeaux.fr/handle/20.500.12278/124002

DOI

http://dx.doi.org/10.3390/brainsci11091127

Unités de recherche

Oenologie - UMR 1366

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Pomegranate juice ameliorates dopamine release and behavioral deficits in a rat model of parkinson’s disease

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