Mostrar el registro sencillo del ítem

Physical activity, incidence and progression of age-related macular degeneration: A multi-cohort study

dc.rights.licenseopenen_US
dc.contributor.authorMAUSCHITZ, Matthias M.
dc.contributor.authorSCHMITZ, Marie Therese
dc.contributor.authorVERZIJDEN, Timo
dc.contributor.authorSCHMID, Matthias
dc.contributor.authorTHEE, Eric F.
dc.contributor.authorCOLIJN, Johanna M.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDELCOURT, Cecile
ORCID: 0000-0002-2099-0481
IDREF: 035105291
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUGNARD-GREGOIRE, Audrey
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMERLE, Benedicte
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOROBELNIK, Jean-Francois
dc.contributor.authorGOPINATH, Bamini
dc.contributor.authorMITCHELL, Paul
dc.contributor.authorELBAZ, Hisham
dc.contributor.authorSCHUSTER, Alexander K.
dc.contributor.authorWILD, Philipp S.
dc.contributor.authorBRANDL, Caroline
dc.contributor.authorSTARK, Klaus J.
dc.contributor.authorHEID, Iris M.
dc.contributor.authorGUNTHER, Felix
dc.contributor.authorPETERS, Annette
dc.contributor.authorKLAVER, Caroline C. W.
dc.contributor.authorFINGER, Robert P.
dc.contributor.authorEUROPEAN EYE EPIDEMIOLOGY, Consortium
dc.date.accessioned2021-12-06T09:11:11Z
dc.date.available2021-12-06T09:11:11Z
dc.date.issued2021-10-22
dc.identifier.issn1879-1891 (Electronic) 0002-9394 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123984
dc.description.abstractEnPURPOSE: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population. DESIGN: Meta-analysis of longitudinal cohort studies. METHODS: We included a total of 14,630 adults with no or early AMD at baseline from seven population-based studies and examined associations of PA with AMD incidence and progression using multi-state models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. MAIN OUTCOME MEASURE: Hazard ratio (HR) for incident early or progression to late AMD. RESULTS: At baseline, mean age ranged from 60.7± 6.9 to 76.4 ± 4.3 years and prevalence of early AMD was 7.7%, ranging from 3.6 to 16.9% between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR 1.19; 95%CI=[1.01, 1.40]; p=0.04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD. CONCLUSIONS: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact.
dc.language.isoENen_US
dc.title.enPhysical activity, incidence and progression of age-related macular degeneration: A multi-cohort study
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ajo.2021.10.008en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34695401en_US
bordeaux.journalAmerican Journal of Ophthalmologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03466673
hal.version1
hal.date.transferred2021-12-06T09:11:35Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Ophthalmology&rft.date=2021-10-22&rft.eissn=1879-1891%20(Electronic)%200002-9394%20(Linking)&rft.issn=1879-1891%20(Electronic)%200002-9394%20(Linking)&rft.au=MAUSCHITZ,%20Matthias%20M.&SCHMITZ,%20Marie%20Therese&VERZIJDEN,%20Timo&SCHMID,%20Matthias&THEE,%20Eric%20F.&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem