DOMBLIDES, Charlotte; SOUBEYRAN, Isabelle; LARTIGUE, Lydia; MAHOUCHE, Isabelle; LEFORT, Félix; VELASCO, Valérie; BARNETCHE, Thomas; BLANCO, Patrick; DECHANET-MERVILLE, Julie; FAUSTIN, Benjamin

doi:10.3390/cancers12123500

Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]

SOUBEYRAN, Isabelle

LARTIGUE, Lydia
Actions for OnCogenesis understanding and Target Identification in ONcology [ACTION]

Langue

Article de revue

Ce document a été publié dans

Cancers. 2020-11-24, vol. 12, n° 12

Résumé en anglais

(1) We wanted to assess the prognostic impact of inflammasomes involved in gut epithelial homeostasis and the development of human colorectal cancer (CRC). (2) We investigated the expression of inflammasome components in colonic epithelial cells at the protein level in patient tissues, through an immunofluorescence assay. (3) In a cohort of 104 patients, we found that all inflammasome components were downregulated in CRC. Loss of epithelial (but not stromal) expression of NLRP6, caspase-1 and IL-18 was associated with an increased mortality of 72%, 58% and 68% respectively and to disease progression into metastasis. The loss of epithelial and stromal IL-18 but not NLRP6, was associated to lower tumor immune infiltrates in the lymphoid compartment and higher Programmed cell Death receptor 1 (PD-1) expression. Finally, we found that combined downregulation of IL-18 and NLRP6 was associated with a worse outcome. Indeed, 5-year survival rates were 26% for the NLRP6low/IL-18low tumors, compared to 64.4% for the entire cohort. This downregulation was associated with a more advanced disease ( < 0.0001) and a trend to lower lymphoid cell infiltration. (4) We identified critical inflammasome markers that may help in better stratifying patients for prognosis in CRC and could help clinicians to determine which patients may benefit from immunotherapies.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123959

DOI

http://dx.doi.org/10.3390/cancers12123500

Unités de recherche

ImmunoConcEpT - UMR 5164

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Prognostic Role of Inflammasome Components in Human Colorectal Cancer.

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche