Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | KAMINSKI, Hannah | |
| dc.contributor.author | MÉNARD, Coline | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | EL HAYANI, Bouchra | |
| dc.contributor.author | ADJIBABI, And-Nan | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | MARSERES, Gabriel | |
| dc.contributor.author | COURANT, Maxime | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | ZOUINE, Atika | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | PITARD, Vincent | |
| dc.contributor.author | GARRIGUE, Isabelle
IDREF: 12258953X | |
| dc.contributor.author | BURREL, Sonia | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | MOREAU, Jean-François | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | COUZI, Lionel | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | VISENTIN, Jonathan | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | MERVILLE, Pierre | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | DÉCHANET-MERVILLE, Julie | |
| dc.date.accessioned | 2021-12-01T09:12:29Z | |
| dc.date.available | 2021-12-01T09:12:29Z | |
| dc.date.issued | 2021-02-24 | |
| dc.identifier.issn | 1537-6613 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123953 | |
| dc.description.abstractEn | Cytomegalovirus (CMV) is a major infectious cause of death and disease after transplantation. We have previously demonstrated that the tissue-associated adaptive Vδ2neg γδ T cells are key effectors responding to CMV and associated with recovery, contrasting with their innatelike circulating counterparts, the Vγ9posVδ2pos T cells that respond to phosphoantigens but not to CMV. A third Vγ9negVδ2pos subgroup with adaptive functions has been described in adults. In the current study, we demonstrate that these Vγ9negVδ2pos T cells are also components of the CMV immune response while presenting with distinct characteristics from Vδ2neg γδ T cells. In a cohort of kidney transplant recipients, CMV seropositivity was the unique clinical parameter associated with Vγ9negVδ2pos T-cell expansion and differentiation. Extensive phenotyping demonstrated their substantial cytotoxic potential and activation during acute CMV primary infection or reinfection. In vitro, Vγ9negVδ2pos T cells responded specifically to CMV-infected cells in a T-cell receptor-dependent manner and through strong interferon γ production. Finally, Vγ9negVδ2pos T cells were the only γδ T-cell subset in which expansion was tightly correlated with the severity of CMV disease. To conclude, our results identify a new player in the immune response against CMV and open interesting clinical perspectives for using Vγ9negVδ2pos T cells as an immune marker for CMV disease severity in immunocompromised patients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Cell Line | |
| dc.subject.en | Cytomegalovirus | |
| dc.subject.en | Cytomegalovirus Infections | |
| dc.subject.en | Female | |
| dc.subject.en | Fibroblasts | |
| dc.subject.en | Humans | |
| dc.subject.en | Immunocompromised Host | |
| dc.subject.en | Interferon-gamma | |
| dc.subject.en | Kidney Transplantation | |
| dc.subject.en | Lymphocyte Activation | |
| dc.subject.en | Male | |
| dc.subject.en | Middle Aged | |
| dc.subject.en | Receptors | |
| dc.subject.en | Antigen | |
| dc.subject.en | T-Cell | |
| dc.subject.en | gamma-delta | |
| dc.subject.en | Severity of Illness Index | |
| dc.subject.en | T-Lymphocyte Subsets | |
| dc.title.en | Characterization of a Unique γδ T-Cell Subset as a Specific Marker of Cytomegalovirus Infection Severity. | |
| dc.title.alternative | J Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/infdis/jiaa400 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 32622351 | en_US |
| bordeaux.journal | Journal of Infectious Diseases | en_US |
| bordeaux.page | 655-666 | en_US |
| bordeaux.volume | 223 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | CHU de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03460730 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-12-01T09:14:43Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
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