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Immunomodulatory treatment and surgical management of idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children: a French survey practice

dc.rights.licenseopenen_US
dc.contributor.authorMOLIMARD, Julie
dc.contributor.authorPAJOT, Christine
dc.contributor.authorOLLE, Priscille
dc.contributor.authorBELOT, Alexandre
dc.contributor.authorQUARTIER, Pierre
dc.contributor.authorUETTWILLER, Florence
dc.contributor.authorCOURET, Chloe
dc.contributor.authorCOSTE, Valentine
dc.contributor.authorCOSTET, Camille
dc.contributor.authorBODAGHI, Bahram
dc.contributor.authorDUREAU, Pascal
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBAILHACHE, Marion
dc.contributor.authorPILLET, Pascal
dc.date.accessioned2021-11-16T08:16:02Z
dc.date.available2021-11-16T08:16:02Z
dc.date.issued2021-09-03
dc.identifier.issn1546-0096 (Electronic) 1546-0096 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123802
dc.description.abstractEnBACKGROUND: Surgeries for idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children are complex because of the high risk of inflammatory postoperative complications. There is no consensus about treatment adaptation during the perioperative period. The objectives of this study are to report the therapeutic changes made in France and to determine whether maintaining or stopping immunosuppressive therapies is associated with an increased risk of surgical site infection or an increased risk of uveitis or arthritis flare-up. METHODS: We conducted a retrospective cohort study between January 1, 2006 and December 31, 2018 in six large University Hospitals in France. Inclusion criteria were chronic idiopathic uveitis or chronic uveitis associated with juvenile idiopathic arthritis under immunosuppressive therapies at the time of the surgical procedure, operated before the age of 16. Data on perioperative treatments, inflammatory relapses and post-operative infections were collected. RESULTS: A total of 76 surgeries (42% cataract surgeries, 30% glaucoma surgeries and 16% posterior capsule opacification surgeries) were performed on 37 children. Adaptation protocols were different in the six hospitals. Immunosuppressive therapies were discontinued in five cases (7%) before surgery. All the children in the discontinuation group had an inflammatory relapse within 3 months after surgery compared to only 25% in the other group. There were no postoperative infections. CONCLUSIONS: The results of this study show varying practices between centres. The benefit-risk balance seems to favour maintaining immunosuppressive therapies during surgery. Further studies are needed to determine the optimal perioperative treatments required to limit post-operative inflammatory relapses.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enArthritis
dc.subject.enJuvenile
dc.subject.enUveitis
dc.subject.enImmunotherapy
dc.subject.enCataract
dc.subject.enGlaucoma
dc.subject.enChild
dc.title.enImmunomodulatory treatment and surgical management of idiopathic uveitis and juvenile idiopathic arthritis-associated uveitis in children: a French survey practice
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12969-021-00626-xen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34479590en_US
bordeaux.journalPediatric Rheumatologyen_US
bordeaux.page139en_US
bordeaux.volume19en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamIETOen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Pediatric%20Rheumatology&rft.date=2021-09-03&rft.volume=19&rft.issue=1&rft.spage=139&rft.epage=139&rft.eissn=1546-0096%20(Electronic)%201546-0096%20(Linking)&rft.issn=1546-0096%20(Electronic)%201546-0096%20(Linking)&rft.au=MOLIMARD,%20Julie&PAJOT,%20Christine&OLLE,%20Priscille&BELOT,%20Alexandre&QUARTIER,%20Pierre&rft.genre=article


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