Elastin-like Polypeptide-Based Bioink: A Promising Alternative for 3D Bioprinting.
| dc.rights.license | open | en_US |
| hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | DAI, Michèle | |
| hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
| dc.contributor.author | BELAÏDI, Jean-Philippe | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 4 LCPO : Polymer Materials for Electronic, Energy, Information and Communication Technologies | |
| dc.contributor.author | FLEURY, Guillaume | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | GARANGER, Elisabeth
IDREF: 089451740 | |
| hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
| dc.contributor.author | RIELLAND, Maïté | |
| hal.structure.identifier | L'Oréal Recherche France [L'Oréal Recherche] | |
| dc.contributor.author | SCHULTZE, Xavier | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 3 LCPO : Polymer Self-Assembly & Life Sciences | |
| dc.contributor.author | LECOMMANDOUX, Sebastien | |
| dc.date.accessioned | 2021-11-12T08:53:11Z | |
| dc.date.available | 2021-11-12T08:53:11Z | |
| dc.date.issued | 2021-11-09 | |
| dc.identifier.issn | 1526-4602 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/123792 | |
| dc.description.abstractEn | Three-dimensional (3D) bioprinting offers a great alternative to traditional techniques in tissue reconstruction, based on seeding cells manually into a scaffold, to better reproduce organs' complexity. When a suitable bioink is engineered with appropriate physicochemical properties, such a process can advantageously provide a spatial control of the patterning that improves tissue reconstruction. The design of an adequate bioink must fulfill a long list of criteria including biocompatibility, printability, and stability. In this context, we have developed a bioink containing a precisely controlled recombinant biopolymer, namely, elastin-like polypeptide (ELP). This material was further chemoselectively modified with cross-linkable moieties to provide a 3D network through photopolymerization. ELP chains were additionally either functionalized with a peptide sequence Gly-Arg-Gly-Asp-Ser (GRGDS) or combined with collagen I to enable cell adhesion. Our ELP-based bioinks were found to be printable, while providing excellent mechanical properties such as stiffness and elasticity in their cross-linked form. Besides, they were demonstrated to be biocompatible, showing viability and adhesion of dermal normal human fibroblasts (NHF). Expressions of specific extracellular matrix (ECM) protein markers as pro-collagen I, elastin, fibrillin, and fibronectin were revealed within the 3D network containing cells after only 18 days of culture, showing the great potential of ELP-based bioinks for tissue engineering. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
| dc.title.en | Elastin-like Polypeptide-Based Bioink: A Promising Alternative for 3D Bioprinting. | |
| dc.title.alternative | Biomacromolecules | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1021/acs.biomac.1c00861 | en_US |
| dc.subject.hal | Chimie/Polymères | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biotechnologies | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux | en_US |
| dc.identifier.pubmed | 34751573 | en_US |
| bordeaux.journal | Biomacromolecules | en_US |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-03426195 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-11-12T08:53:18Z | |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | CC BY-NC-SA | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2021-11-09&rft.eissn=1526-4602&rft.issn=1526-4602&rft.au=DAI,%20Mich%C3%A8le&BELA%C3%8FDI,%20Jean-Philippe&FLEURY,%20Guillaume&GARANGER,%20Elisabeth&RIELLAND,%20Ma%C3%AFt%C3%A9&rft.genre=article |
