DALLET, Laurence; STANICKI, Dimitri; VOISIN, Pierre; MIRAUX, Sylvain; RIBOT, Emeline J

doi:10.1038/s41598-021-82095-6

Centre de résonance magnétique des systèmes biologiques [CRMSB]

STANICKI, Dimitri

VOISIN, Pierre
Centre de résonance magnétique des systèmes biologiques [CRMSB]

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Article de revue

Ce document a été publié dans

Scientific Reports. 2021-02-08, vol. 11, n° 1, p. 3286

Résumé en anglais

Iron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r relaxivities (100 mM s) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.< Réduire

URI

https://oskar-bordeaux.fr/handle/20.500.12278/123785

DOI

http://dx.doi.org/10.1038/s41598-021-82095-6

Lien vers les données de la recherche

10.1038/s4159 8-021-82095 -6

Project ANR

Magnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017

Unités de recherche

Centre de Résonance Magnétique des Systèmes Biologiques (CRMSB) - UMR 5536

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Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment.