Show simple item record

dc.rights.licenseopenen_US
dc.contributor.authorDE HEUS, Rianne A. A.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTZOURIO, Christophe
IDREF: 69829209
dc.contributor.authorLEE, Emily Jo Lynn
dc.contributor.authorOPOZDA, Melissa
dc.contributor.authorVINCENT, Andrew D.
dc.contributor.authorANSTEY, Karrin J.
dc.contributor.authorHOFMAN, Albert
dc.contributor.authorKARIO, Kazuomi
dc.contributor.authorLATTANZI, Simona
dc.contributor.authorLAUNER, Lenore J.
dc.contributor.authorMA, Yuan
dc.contributor.authorMAHAJAN, Rajiy
dc.contributor.authorMOOIJAART, Simon P.
dc.contributor.authorNAGAI, Michiaki
dc.contributor.authorPETERS, Ruth
dc.contributor.authorTURNBULL, Deborah
dc.contributor.authorYANO, Yuichiro
dc.contributor.authorCONSORTIUM, Variable Brain
dc.contributor.authorCLAASSEN, Jahr
dc.contributor.authorTULLY, Phillip J.
dc.date.accessioned2021-11-08T14:32:56Z
dc.date.available2021-11-08T14:32:56Z
dc.date.issued2021-09-20
dc.identifier.issn1524-4563 (Electronic) 0194-911X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/123781
dc.description.abstractEnResearch links high blood pressure variability (BPV) with stroke and cerebrovascular disease, however, its association with cognition remains unclear. Moreover, it remains uncertain which BP-derived parameter (ie, variability or mean) holds more significance in understanding vascular contributions to cognitive impairment. We searched PubMed, Embase, PsycINFO, and Scopus and performed a meta-analysis of studies that quantified the association between resting BPV with dementia or cognitive impairment in adults. Two authors independently reviewed all titles, abstracts, and full-texts and extracted data, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-Analysis of Observational Studies in Epidemiology guidelines. Study quality was assessed using the (modified) Newcastle-Ottawa Scale. A multilevel meta-analysis was used, which included effect sizes for both BPV and mean BP, with a combined end point of dementia or cognitive impairment as primary outcome. In the primary analysis, 54 effect sizes were extracted from 20 studies, with a total analytical sample of n=7 899 697. Higher systolic BPV (odds ratio [OR], 1.25 [95% CI, 1.16-1.35]), mean systolic pressure (OR, 1.12 [95% CI, 1.02-1.29]), diastolic BPV (OR, 1.20 [95% CI, 1.12-1.29]), and mean diastolic pressure (OR, 1.16 [95% CI, 1.04-1.29]) were associated with dementia and cognitive impairment. A direct comparison showed that mean BP effect sizes were less strong than BPV effect sizes (OR, 0.92 [95% CI, 0.87-0.97], P<0.01), indicating that the relative contribution of BPV exceeded that of mean BP. Methodological and statistical heterogeneity was high. Secondary analyses were less consistent as to whether BPV and mean BP were differentially associated with dementia subtypes and cognitive domains. Future studies are required to investigate BPV as a target for dementia prevention.
dc.language.isoENen_US
dc.subject.enMeta-analysis
dc.subject.enCerebrovascular disorders
dc.subject.enBlood pressure
dc.subject.enHemodynamics
dc.subject.enStroke
dc.subject.enDementia
dc.subject.enAlzheimer disease
dc.title.enAssociation Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/hypertensionaha.121.17797en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34538105en_US
bordeaux.journalHypertensionen_US
bordeaux.page1478–1489en_US
bordeaux.volume78en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03419564
hal.version1
hal.date.transferred2021-11-08T14:33:04Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Hypertension&amp;rft.date=2021-09-20&amp;rft.volume=78&amp;rft.issue=5&amp;rft.spage=1478%E2%80%931489&amp;rft.epage=1478%E2%80%931489&amp;rft.eissn=1524-4563%20(Electronic)%200194-911X%20(Linking)&amp;rft.issn=1524-4563%20(Electronic)%200194-911X%20(Linking)&amp;rft.au=DE%20HEUS,%20Rianne%20A.%20A.&amp;TZOURIO,%20Christophe&amp;LEE,%20Emily%20Jo%20Lynn&amp;OPOZDA,%20Melissa&amp;VINCENT,%20Andrew%20D.&amp;rft.genre=article


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record