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Assessment of Liver Disease Progression in Cystic Fibrosis Using Transient Elastography

dc.rights.licenseopenen_US
dc.contributor.authorGOMINON, Anne-Laure
dc.contributor.authorFRISON, Eric
dc.contributor.authorHIRIART, Jean-Baptiste
dc.contributor.authorVERGNIOL, Julien
dc.contributor.authorCLOUZEAU, Haude
dc.contributor.authorENAUD, Raphael
dc.contributor.authorBUI, Stephanie
dc.contributor.authorFAYON, Michael
dc.contributor.authorDE LEDINGHEN, Victor
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLAMIREAU, Thierry
dc.date.accessioned2020-11-10T14:32:47Z
dc.date.available2020-11-10T14:32:47Z
dc.date.issued2018-03
dc.identifier.issn1536-4801 (Electronic) 0277-2116 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/12213
dc.description.abstractEnOBJECTIVES: Cystic fibrosis-related liver disease (CFLD) can develop silently in early life and approximately 10% of children with cystic fibrosis (CF) become cirrhotic before adulthood. Clinical, biological, and ultrasound criteria used to define CFLD often reveal liver involvement at an advanced stage. The aim of this retrospective study was to assess the progression of liver stiffness measurement (LSM) in pediatric patients with CF. METHODS: The change of LSM, expressed as kPa/year and %/year, was measured using transient elastography (Fibroscan) in 82 children with CF (median age: 6.8 years, interquartile range [IQR]: 5.8). Mean time interval between the 2 LSM was 3.5 years. RESULTS: Median initial liver stiffness was 3.7 kPa (IQR: 1.3), and then progressed by 0.23 kPa/year, that is, 6%/year. The 7 patients who developed CFLD had a higher initial level of alanine aminotransferase (50 [IQR: 15] vs 30 [IQR: 18], P = 0.0001) and presented a more rapid progression of LSM (0.94 vs 0.23 kPa/year, P = 0.02). CONCLUSIONS: The present study shows that the slope of worsening of liver stiffness is greater in patients who will develop CFLD, suggesting that annual transient elastography may be useful to detect risk of severe liver disease at an earlier stage.
dc.language.isoENen_US
dc.subject.enLEHA
dc.subject.enUSMR
dc.title.enAssessment of Liver Disease Progression in Cystic Fibrosis Using Transient Elastography
dc.title.alternativeJ Pediatr Gastroenterol Nutren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/mpg.0000000000001822en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29112089en_US
bordeaux.journalJournal of Pediatric Gastroenterology and Nutritionen_US
bordeaux.page455-460en_US
bordeaux.volume66en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamLEHA_BPH
bordeaux.teamUSMRen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194289
hal.version1
hal.date.transferred2021-04-09T12:18:36Z
hal.exporttrue
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