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Alterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer

dc.rights.licenseopenen_US
dc.contributor.authorFRASCA, M.
dc.contributor.authorSOUBEYRAN, P.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBELLERA, Carine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAINFRAY, Muriel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLEFFONDRE, Karen
IDREF: 183599128
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
dc.date.accessioned2020-11-10T09:36:29Z
dc.date.available2020-11-10T09:36:29Z
dc.date.issued2018-02
dc.identifier.issn1879-0852 (Electronic) 0959-8049 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/12181
dc.description.abstractEnINTRODUCTION: A comprehensive geriatric assessment (CGA) evaluating several domains of health is recommended for elderly patients with cancer. Effects of altered domains on the risk of death in this population need to be clarified. The aim of this study was to estimate the independent association of each CGA domain to overall survival (OS). METHOD: Patients included in the ONCODAGE cohort completed a CGA at baseline. Cox models (one per domain) estimated the hazard ratio (HR) of death for each CGA domain. Directed Acyclic Graphs (DAGs) selected specific sets of adjustment factors for each model. RESULTS: The analysis included 1264 patients (mean age: 78 years, women: 70%). Median follow-up was 5.2 years, and 446 patients died. Each altered domain had a detrimental effect on survival, sometimes dependent on gender, age, education or time from inclusion. Nutritional status had a time-varying effect, with higher mortality rates if altered only within the first 3 years of follow-up. In case of altered mobility, the risk of death was higher only for the youngest patients and, in case of altered autonomy, only for the youngest women. An altered neurological state led to higher mortality rates; this effect increased with the level of education. Patients with altered psychological status or more than four comorbidities at baseline had also higher mortality rates. CONCLUSIONS: Patients with an altered CGA domain have a higher risk of death than those without any alteration. The effect of some alterations is different in some subgroups or at a given time of the treatments.
dc.language.isoENen_US
dc.subject.enBiostatistics
dc.subject.enCIC1401
dc.subject.enEPICENE
dc.title.enAlterations in comprehensive geriatric assessment decrease survival of elderly patients with cancer
dc.title.alternativeEur J Canceren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ejca.2017.11.013en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29268140en_US
bordeaux.journalEuropean journal of canceren_US
bordeaux.page10-18en_US
bordeaux.volume90en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamCIC1401en_US
bordeaux.teamEPICENE_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03193853
hal.version1
hal.date.transferred2021-04-09T08:10:43Z
hal.exporttrue
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