EPELBAUM, S.; BOUTELOUP, V.; MANGIN, J. F.; LA CORTE, V.; MIGLIACCIO, R.; BERTIN, H.; HABERT, M. O.; FISCHER, C.; AZOUANI, C.; FILLON, L.; CHUPIN, M.; VELLAS, B.; PASQUIER, F.; DARTIGUES, Jean-Francois; BLANC, F.; GABELLE, A.; CECCALDI, M.; KROLAK-SALMON, P.; HUGON, J.; HANON, O.; ROUAUD, O.; DAVID, R.; CHENE, Geneviève; DUBOIS, B.; DUFOUIL, Carole

doi:10.1016/j.trci.2018.03.010

Idioma

Article de revue

Este ítem está publicado en

Alzheimer's & dementia (New York, N. Y.). 2018-05-22, vol. 4, p. 224-233

Resumen en inglés

Introduction: The free and cued selective reminding test is used to identify memory deficits in mild cognitive impairment and demented patients. It allows assessing three processes: encoding, storage, and recollection of verbal episodic memory. Methods: We investigated the neural correlates of these three memory processes in a large cohort study. The Memento cohort enrolled 2323 outpatients presenting either with subjective cognitive decline or mild cognitive impairment who underwent cognitive, structural MRI and, for a subset, fluorodeoxyglucose-positron emission tomography evaluations. Results: Encoding was associated with a network including parietal and temporal cortices; storage was mainly associated with entorhinal and parahippocampal regions, bilaterally; retrieval was associated with a widespread network encompassing frontal regions. Discussion: The neural correlates of episodic memory processes can be assessed in large and standardized cohorts of patients at risk for Alzheimer's disease. Their relation to pathophysiological markers of Alzheimer's disease remains to be studied.< Leer menos

Palabras clave en inglés

SEPIA

CIC1401

VINTAGE

URI

https://oskar-bordeaux.fr/handle/20.500.12278/12164

DOI

http://dx.doi.org/10.1016/j.trci.2018.03.010

Centros de investigación

Bordeaux Population Health Research Center (BPH) - UMR 1219

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

Neural correlates of episodic memory in the Memento cohort

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación