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Twenty-Four-Hour Central Pulse Pressure for Cardiovascular Events Prediction in a Low-Cardiovascular-Risk Population: Results From the Bordeaux Cohort

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCREMER, Antoine
dc.contributor.authorBOULESTREAU, R.
dc.contributor.authorGAILLARD, P.
dc.contributor.authorLAINE, M.
dc.contributor.authorPAPAIOANNOU, G.
dc.contributor.authorGOSSE, P.
dc.date.accessioned2020-11-02T12:55:51Z
dc.date.available2020-11-02T12:55:51Z
dc.date.issued2018-02-23
dc.identifier.issn2047-9980en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11577
dc.description.abstractEnBACKGROUND: Central blood pressure (BP) is a promising marker to identify subjects with higher cardiovascular risk than expected by traditional risk factors. Significant results have been obtained in populations with high cardiovascular risk, but little is known about low-cardiovascular-risk patients, although the differences between central and peripheral BP (amplification) are usually greater in this population. The study aim was to evaluate central BP over 24 hours for cardiovascular event prediction in hypertensive subjects with low cardiovascular risk. METHODS AND RESULTS: Peripheral and central BPs were recorded during clinical visits and over 24 hours in hypertensive patients with low cardiovascular risk (Systematic Coronary Risk Evaluation </=5%). Our primary end point is the occurrence of a cardiovascular event during follow-up. To assess the potential interest in central pulse pressure over 24 hours, we performed Cox proportional hazard models analysis and comparison of area under the curves using the contrast test for peripheral and central BP. A cohort of 703 hypertensive subjects from Bordeaux were included. After the first 24 hours of BP measurement, the subjects were then followed up for an average of 112.5+/-70 months. We recorded 65 cardiovascular events during follow-up. Amplification was found to be significantly associated with cardiovascular events when added to peripheral 24-hour pulse pressure (P=0.0259). The area under the curve of 24-hour central pulse pressure is significantly more important than area under the curve of office BP (P=0.0296), and there is a trend of superiority with the area under the curve of peripheral 24-hour pulse pressure. CONCLUSIONS: Central pulse pressure over 24 hours improves the prediction of cardiovascular events for hypertensive patients with low cardiovascular risk compared to peripheral pulse pressure.
dc.language.isoENen_US
dc.subject.enVINTAGE
dc.title.enTwenty-Four-Hour Central Pulse Pressure for Cardiovascular Events Prediction in a Low-Cardiovascular-Risk Population: Results From the Bordeaux Cohort
dc.title.alternativeJ Am Heart Assocen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1161/jaha.117.008225en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29475873en_US
bordeaux.journalJournal of the American Heart Associationen_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-02985691
hal.version1
hal.date.transferred2020-11-02T12:55:55Z
hal.exporttrue
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