The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination
| dc.rights.license | open | en_US |
| dc.contributor.author | LAITMAN, Benjamin M. | |
| dc.contributor.author | ASP, Linnéa | |
| dc.contributor.author | MARIANI, John N. | |
| dc.contributor.author | ZHANG, Jingya | |
| dc.contributor.author | LIU, Jia | |
| dc.contributor.author | SAWAI, Setsu | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | CHAPOULY, Candice | |
| dc.contributor.author | HORNG, Sam | |
| dc.contributor.author | KRAMER, Elisabeth G. | |
| dc.contributor.author | MITIKU, Nesanet | |
| dc.contributor.author | LOO, Hannah | |
| dc.contributor.author | BURLANT, Natalie | |
| dc.contributor.author | PEDRE, Xiomara | |
| dc.contributor.author | HARA, Yuko | |
| dc.contributor.author | NUDELMAN, German | |
| dc.contributor.author | ZASLAVSKY, Elena | |
| dc.contributor.author | LEE, Young-Min | |
| dc.contributor.author | BRAUN, David A. | |
| dc.contributor.author | LU, Q. Richard | |
| dc.contributor.author | NARLA, Goutham | |
| dc.contributor.author | RAINE, Cedric S. | |
| dc.contributor.author | FRIEDMAN, Scott L. | |
| dc.contributor.author | CASACCIA, Patrizia | |
| dc.contributor.author | JOHN, Gareth R. | |
| dc.date.accessioned | 2020-10-27T15:50:01Z | |
| dc.date.available | 2020-10-27T15:50:01Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1545-7885 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/11529 | |
| dc.description.abstractEn | Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional activator Krüppel-like factor-6 (Klf6). Klf6 is rapidly induced in oligodendrocyte progenitors (OLP) by gp130 factors, and promotes differentiation. Conversely, in mice with lineage-selective Klf6 inactivation, OLP undergo maturation arrest followed by apoptosis, and CNS myelination fails. Overlapping transcriptional and chromatin occupancy analyses place Klf6 at the nexus of a novel gp130-Klf-importin axis, which promotes differentiation and viability in part via control of nuclear trafficking. Klf6 acts as a gp130-sensitive transactivator of the nuclear import factor importin-α5 (Impα5), and interfering with this mechanism interrupts step-wise differentiation. Underscoring the significance of this axis in vivo, mice with conditional inactivation of gp130 signaling display defective Klf6 and Impα5 expression, OLP maturation arrest and apoptosis, and failure of CNS myelination. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | |
| dc.subject | *Article RECHERCHE | |
| dc.subject.en | Alpha Karyopherins | |
| dc.subject.en | Animals | |
| dc.subject.en | Cell Differentiation | |
| dc.subject.en | Cell Survival | |
| dc.subject.en | Central Nervous System | |
| dc.subject.en | Chromatin | |
| dc.subject.en | Cytokine Receptor Gp130 | |
| dc.subject.en | Developmental | |
| dc.subject.en | Embryo | |
| dc.subject.en | Gene Expression Regulation | |
| dc.subject.en | Inbred C57bl | |
| dc.subject.en | Kruppel-Like Factor 6 | |
| dc.subject.en | Kruppel-Like Transcription Factors | |
| dc.subject.en | Mammalian | |
| dc.subject.en | Mice | |
| dc.subject.en | Myelin Sheath | |
| dc.subject.en | Oligodendroglia | |
| dc.subject.en | Proto-Oncogene Proteins | |
| dc.subject.en | Signal Transduction | |
| dc.subject.en | Stat3 Transcription Factor | |
| dc.subject.en | Stem Cells | |
| dc.subject.en | Transgenic | |
| dc.title.en | The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1371/journal.pbio.1002467 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 27213272 | en_US |
| bordeaux.journal | PLOS BIOLOGY | en_US |
| bordeaux.page | e1002467 | en_US |
| bordeaux.volume | 14 | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires - U1034 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-02980957 | |
| hal.version | 1 | |
| hal.date.transferred | 2020-10-27T15:50:09Z | |
| hal.export | true | |
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