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Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment

dc.rights.licenseopenen_US
dc.contributor.authorCLOITRE, A.
dc.contributor.authorROSA, R. W.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorARRIVE, Elise
dc.contributor.authorFRICAIN, J. C.
dc.date.accessioned2020-10-27T15:27:39Z
dc.date.available2020-10-27T15:27:39Z
dc.date.issued2018-03-01
dc.identifier.issn1698-4447en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11527
dc.description.abstractEnBACKGROUND: Oral cancer is a public health issue worldwide. Oral potentially malignant disorders (OMPDs) are lesions of the oral mucosa that are predisposed to malignant transformation. The mainstay of OMPDs treatment around the world is now the carbon dioxide (CO2) laser but the reported recurrence and malignant transformation rates vary widely in the literature. We aimed to estimate the recurrence and the malignant transformation rates of OPMDs treated with CO2 laser at the University Hospital of Bordeaux, in France, from 2010 to 2014, and to identify associated factors with recurrence or malignant transformation. MATERIAL AND METHODS: We conducted a retrospective study in patients with a minimum follow-up of 12 months. Collected variables included characteristics of the patients (gender, age, alcohol and tobacco consumption, previous diagnosis of graft-versus-host disease, previous treatments for OPMD or for upper aerodigestive tract cancers and human immunodeficiency virus infection), characteristics of the lesions (form, colour, size, location, degree of dysplasia), laser treatment outcome (complications, recurrence, malignant transformation). RESULTS: Twenty-five patients were included. Mean follow-up was 28.9 months. Recurrence was observed in 11 patients (44%). Annual recurrence rate was 18.3% and annual malignant transformation rate was 1.7%. Hyperplasia without dysplasia was the only factor found to be statistically associated with recurrence. CONCLUSIONS: Our results suggest that OMPDs treated by CO2 laser vaporization have high recurrence rates, particularly those presenting hyperplasia. A standardized definition of recurrence would be necessary for inter-study comparisons. Long-term follow-up is recommended in order to detect and treat squamous cell carcinoma in its early stages.
dc.language.isoENen_US
dc.subject.enIDLIC
dc.title.enOutcome of CO2 laser vaporization for oral potentially malignant disorders treatment
dc.title.alternativeMed Oral Patol Oral Cir Bucalen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.4317/medoral.21984en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed29476671en_US
bordeaux.journalMedicina oral, patologia oral y cirugia bucalen_US
bordeaux.pagee237-e247en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03162257
hal.version1
hal.date.transferred2021-03-08T12:43:07Z
hal.exporttrue
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