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Are platelet transfusions harmful in acquired thrombotic thrombocytopenic purpura at the acute phase? Experience of the French thrombotic microangiopathies reference center.

dc.rights.licenseopenen_US
dc.contributor.authorBENHAMOU. Y
dc.contributor.authorBAUDEL, J. L.
dc.contributor.authorWYNCKEL, A.
dc.contributor.authorGALICIER, L.
dc.contributor.authorAZOULAY, E.
dc.contributor.authorPROVÔT, F.
dc.contributor.authorPÈNE, F.
dc.contributor.authorMIRA, J. P.
dc.contributor.authorPRESNE, C.
dc.contributor.authorPOULLIN, P.
dc.contributor.authorHALIMI, J. M.
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRIVIERE, E.
dc.contributor.authorKANOUNI, T.
dc.contributor.authorSEQUIN, A.
dc.contributor.authorMOUSSON, C.
dc.contributor.authorSERVAIS, A.
dc.contributor.authorBORDESSOULE, D.
dc.contributor.authorPEREZ, P.
dc.contributor.authorHAMIDOU, M.
dc.contributor.authorCHAUVEAU, D.
dc.contributor.authorVEYRADIER, A.
dc.contributor.authorCOPPO, P.
dc.date.accessioned2020-10-27T13:10:27Z
dc.date.available2020-10-27T13:10:27Z
dc.date.issued2015-06
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11497
dc.description.abstractEnTo the Editor: Thrombotic thrombocytopenic purpura (TTP) is a specific form of thrombotic microangiopathy (TMA) characterized by thrombocytopenia, erythrocyte fragmentation, and widespread microvascular thrombi responsible for multi-organ failure of variable severity [1]. Surprisingly, while a profound thrombocytopenia is a typical feature of the disease, severe hemorrhage is a rare cause of mortality. Nevertheless, in case of severe bleeding or when an invasive procedure is needed (i.e., catheter insertion, spinal puncture), platelets transfusion may be required, although sudden clinical deteriorations and fatalities suggestive of a worsening of TTP within few hours after a platelet transfusion were reported [2,3]. To date, controversies remain on the effect of platelet transfusions during TTP [4–6]. In light of the uncertain risk of platelet transfusions in TTP and the lack of recently published data, we retrospectively reviewed admission data of all TTP patients with a severe acquired ADAMTS13 deficiency (\textless10% of activity in normal plasma) enrolled in the French TMA Reference Centre registry, in order to better assess the risk of platelet transfusions at the acute phase of TTP. ...
dc.language.isoENen_US
dc.subjectArticle CLINIQUE
dc.title.enAre platelet transfusions harmful in acquired thrombotic thrombocytopenic purpura at the acute phase? Experience of the French thrombotic microangiopathies reference center.
dc.title.alternativeAm J Hematolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/ajh.23997en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalAmerican Journal of Hematologyen_US
bordeaux.pageE127–129en_US
bordeaux.volume90(6)en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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