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Infectious events and associated risk factors in mycosis fungoides/Sezary syndrome: a retrospective cohort study

dc.rights.licenseopenen_US
dc.contributor.authorBLAIZOT, R.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorOUATTARA, Eric
dc.contributor.authorFAUCONNEAU, A.
dc.contributor.authorBEYLOT-BARRY, M.
dc.contributor.authorPHAM-LEDARD, A.
dc.date.accessioned2020-10-26T08:36:49Z
dc.date.available2020-10-26T08:36:49Z
dc.date.issued2018-12
dc.identifier.issn1365-2133 (Electronic) 0007-0963 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11466
dc.description.abstractEnBACKGROUND: Infections are one of the major causes of death in patients with advanced-stage mycosis fungoides (MF) or Sezary syndrome (SS). However, few recent data are available on the characteristics and risk factors of these infectious events. OBJECTIVES: To describe infectious events occurring in a cohort of patients with MF/SS, and to identify associated clinical and biological risk factors. METHODS: A retrospective cohort study was performed to investigate infectious events and associated factors in patients diagnosed with MF (stage IB and beyond) or SS followed from May 2011 to May 2016 at the University Hospital of Bordeaux, France. RESULTS: Seventy-one patients with complete follow-up were included. Eighty infectious events were recorded in 40 patients, including 28 skin and soft tissue infections and 25 cases of pneumonia. Opportunistic infections, which are usually associated with depleted cell-mediated immunity, were scarce (9%). In multivariate analysis, cardiac, renal or lung comorbidities [odds ratio (OR) 7.2, 95% confidence interval (CI) 3.3-15.9; P = 0.002], SS (OR 8.8, 95% CI 7.7-10.2; P = 0.037) and lymphocyte count < 0.5 x 10(9) cells L(-1) (OR 6.4, 95% CI 1.5-27.4; P = 0.004) were significantly associated with a higher risk of infection. CONCLUSIONS: Opportunistic germs were rarely recorded, but their incidence was probably prevented by adequate prophylaxis (ongoing in 28% of patients). As in patients living with AIDS, pneumonias were frequent. On the other hand, bacterial cutaneous infections represent a specific pattern in patients with MF/SS. Patients with chronic organ failure, lymphocytopenia and SS should be considered as being at high risk for infectious events. Pneumococcal vaccination should be systematically recommended, and prophylaxis with co-trimoxazole and valaciclovir when the CD4 count is < 0.2 x 10(9) cells L(-1) .
dc.language.isoENen_US
dc.subject.enIDLIC
dc.subject.enPACCI
dc.title.enInfectious events and associated risk factors in mycosis fungoides/Sezary syndrome: a retrospective cohort study
dc.title.alternativeBr J Dermatolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/bjd.17073en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed30098016en_US
bordeaux.journalThe British Journal of Dermatologyen_US
bordeaux.page1322-1328en_US
bordeaux.volume179en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03164799
hal.version1
hal.date.transferred2021-03-10T10:01:53Z
hal.exporttrue
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