Aging with HIV: what effect on mortality and loss to follow-up in the course of antiretroviral therapy? The IeDEA West Africa Cohort Collaboration
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BERNARD, Charlotte | |
| dc.contributor.author | BALESTRE, E. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COFFIE, Patrick A. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | EHOLIE, Serge Paul | |
| dc.contributor.author | MESSOU, Eugene | |
| dc.contributor.author | KWAGHE, V. | |
| dc.contributor.author | OKWARA, B. | |
| dc.contributor.author | SAWADOGO, A. | |
| dc.contributor.author | ABO, Y. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DABIS, Francois | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DE REKENEIRE, Nathalie | |
| dc.date.accessioned | 2020-10-20T07:59:00Z | |
| dc.date.available | 2020-10-20T07:59:00Z | |
| dc.date.issued | 2018-11-16 | |
| dc.identifier.issn | 1179-1373 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/11451 | |
| dc.description.abstractEn | Background: Reporting mortality and lost to follow-up (LTFU) by age is essential as older HIV-positive patients might be at risk of long-term effects of living with HIV and/or taking antiretroviral therapy (ART). As age effects might not be linear and might impact HIV outcomes in the oldest more severely, people living with HIV (PLHIV) aged 50-59 years and PLHIV aged >60 years were considered separately. Setting: Seventeen adult HIV/AIDS clinics spread over nine countries in West Africa. Methods: Data were collected within the International Epidemiological Databases to Evaluate AIDS West Africa Collaboration. ART-naive PLHIV-1 adults aged >16 years initiating ART and attending >= 2 clinic visits were included (N=73,525). Age was divided into five groups: 16-29/30-39/40-49/50-59/>= 60 years. The age effect on mortality and LTFU was evaluated with Kaplan-Meier curves and multivariable Cox proportional hazard regressions. Results: At month 36, 5.9% of the patients had died and 47.3% were LTFU. Patients aged >= 60 (N=1,736) and between 50-59 years old (N=6,792) had an increased risk of death in the first 36 months on ART (adjusted hazard ratio=1.66; 95% CI: 1.36-2.03 and adjusted hazard ratio=1.31; 95% CI: 1.15-1.49, respectively; reference: <30 years old). Patients >= 60 years old tend to be more often LTFU. Condusion: The oldest PLHIV presented the poorest outcomes, suggesting that the PLHIV aged >50 years old should not be considered as a unique group irrespective of their age. Tailored programs focusing on improving the care services for older PLHIV in Sub-Saharan Africa are clearly needed to improve basic program outcomes. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/us/ | * |
| dc.subject.en | IDLIC | |
| dc.subject.en | Coll_IeDEA | |
| dc.title.en | Aging with HIV: what effect on mortality and loss to follow-up in the course of antiretroviral therapy? The IeDEA West Africa Cohort Collaboration | |
| dc.title.alternative | Hiv Aids (Auckl) | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2147/hiv.S172198 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| bordeaux.journal | HIV AIDS-RESEARCH AND PALLIATIVE CARE | |
| bordeaux.page | 239-252 | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03163294 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-03-09T09:55:28Z | |
| hal.export | true | |
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