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Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019

dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRUBIN, Sebastien
dc.contributor.authorORIEUX, Arthur
dc.contributor.authorPREVEL, Renaud
dc.contributor.authorGARRIC, Antoine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorBATS, Marie-Lise
dc.contributor.authorDABERNAT, Sandrine
dc.contributor.authorCAMOU, Fabrice
dc.contributor.authorGUISSET, Olivier
dc.contributor.authorISSA, Nahema
dc.contributor.authorMOURISSOUX, Gaelle
dc.contributor.authorDEWITTE, Antoine
dc.contributor.authorJOANNES-BOYAU, Olivier
dc.contributor.authorFLEUREAU, Catherine
dc.contributor.authorROZÉ, Hadrien
dc.contributor.authorCARRIÉ, Cédric
dc.contributor.authorPETIT, Laurent
dc.contributor.authorCLOUZEAU, Benjamin
dc.contributor.authorSAZIO, Charline
dc.contributor.authorBUI, Hoang-Nam
dc.contributor.authorPILLET, Odile
dc.contributor.authorRIGOTHIER, Claire
dc.contributor.authorVARGAS, Frederic
dc.contributor.authorCOMBE, Christian
dc.contributor.authorGRUSON, Didier
dc.contributor.authorBOYER, Alexandre
dc.date.accessioned2020-10-19T12:46:05Z
dc.date.available2020-10-19T12:46:05Z
dc.date.issued2020-08-19
dc.identifier.issn2048-8505, 2048-8513en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/11421
dc.description.abstractEnAbstract Background Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported. Methods Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated. Results Seventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12–23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54–140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively. Conclusion Severe COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial 3.0 United States
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/
dc.subject.enClinique
dc.title.enCharacterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ckj/sfaa099en_US
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologieen_US
bordeaux.journalClinical Kidney Journalen_US
bordeaux.pagesfaa099en_US
bordeaux.hal.laboratoriesBiologie des maladies cardiovasculaires - U1034en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03194408
hal.version1
hal.date.transferred2021-04-09T13:08:24Z
hal.exporttrue
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